Gut microbial colonisation in premature neonates predicts neonatal sepsis

• Published in: Archives of disease in childhood. Fetal and neonatal edition Vol. 97; no. 6; pp. F456 - F462
• Main Authors: Madan, Juliette C, Salari, Richard Cowper, Saxena, Deepti, Davidson, Lisa, O'Toole, George A, Moore, Jason H, Sogin, Mitchell L, Foster, James A, Edwards, William H, Palumbo, Paul, Hibberd, Patricia L
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01.11.2012; BMJ Publishing Group LTD
• Subjects: Anti-Bacterial Agents - therapeutic use; Antibiotics; Bacteria; Bacterial Translocation; Base Sequence; Birth weight; Breastfeeding & lactation; Clostridium; Colonization; Colony Count, Microbial; Deoxyribonucleic acid; DNA; Enterobacteriaceae - genetics; Enterobacteriaceae - isolation & purification; Gastrointestinal Tract - microbiology; Human subjects; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases - drug therapy; Infant, Premature, Diseases - microbiology; Infant, Very Low Birth Weight; Infants; Intensive care; Klebsiella; Laboratories; Lactobacillus; Lifesaving; Longitudinal Studies; Meconium - microbiology; Molecular Sequence Data; Mortality; Neonates; Pathogens; Premature birth; Risk Factors; RNA, Messenger; Sepsis; Sepsis - microbiology; Staphylococcus; Staphylococcus - genetics; Staphylococcus - isolation & purification; Studies; Translocation

Background Neonatal sepsis due to intestinal bacterial translocation is a major cause of morbidity and mortality. Understanding microbial colonisation of the gut in prematurity may predict risk of sepsis to guide future strategies to manipulate the microbiome. Methods Prospective longitudinal study...