Progranulin in frontotemporal lobar degeneration and neuroinflammation

• Published in: Journal of neuroinflammation Vol. 4; no. 1; p. 7
• Main Authors: Ahmed, Zeshan, Mackenzie, Ian RA, Hutton, Michael L, Dickson, Dennis W
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.02.2007; BioMed Central; BMC
• Subjects: Amino Acid Sequence; Animals; Brain - metabolism; Brain - pathology; Central Nervous System Diseases - genetics; Central Nervous System Diseases - metabolism; Central Nervous System Diseases - pathology; Dementia - genetics; Dementia - metabolism; Dementia - pathology; Humans; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; Intercellular Signaling Peptides and Proteins - biosynthesis; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - physiology; Microglia - metabolism; Microglia - pathology; Molecular Sequence Data; Mutation; Review; Up-Regulation - physiology

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries of mutations in the gene for PGRN that cause frontotemporal lobar degeneration (FTLD). Pathogenic mutations in PGRN result in null alleles, and the disease is likely the re...