Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting

Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage re...

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Published inGut Vol. 69; no. 4; pp. 764 - 780
Main Authors Avila, Matias A, Dufour, Jean-François, Gerbes, Alexander L, Zoulim, Fabien, Bataller, Ramon, Burra, Patrizia, Cortez-Pinto, Helena, Gao, Bin, Gilmore, Ian, Mathurin, Philippe, Moreno, Christophe, Poznyak, Vladimir, Schnabl, Bernd, Szabo, Gyongyi, Thiele, Maja, Thursz, Mark R
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.04.2020
BMJ Publishing Group Ltd
BMJ Publishing Group LTD
BMJ Publishing Group
Subjects
Age
Alcohol
Alcohol use
Alcoholic liver disease
Cancer
Chronic illnesses
Cirrhosis
Clinical trials
Epidemiology
Fibrosis
Hepatitis
Humans
Inflammation
Life Sciences
Liver cancer
Liver cirrhosis
Liver diseases
Liver Diseases, Alcoholic - diagnosis
Liver Diseases, Alcoholic - epidemiology
Liver Diseases, Alcoholic - therapy
Liver transplantation
Liver transplants
Metabolism
Metabolites
Mortality
Primary care
Recent advances in clinical practice
Socioeconomic factors
Studies
United States > US
Europe
Spain
alcohol
alcoholic liver disease
fibrosis
cirrhosis
liver transplantation
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Abstract Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing clinical trials spur scientific interest in this area.In April 2019, Gut convened a round table panel of experts during the European Association for the Study of the Liver International Liver Congress in Vienna to discuss critical and up-to-date issues and clinical trial data regarding ALD, its epidemiology, diagnosis, management, pathomechanisms, possible future treatments and prevention. This paper summarises the discussion and its conclusions.
AbstractList Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing clinical trials spur scientific interest in this area.In April 2019, Gut convened a round table panel of experts during the European Association for the Study of the Liver International Liver Congress in Vienna to discuss critical and up-to-date issues and clinical trial data regarding ALD, its epidemiology, diagnosis, management, pathomechanisms, possible future treatments and prevention. This paper summarises the discussion and its conclusions.
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing clinical trials spur scientific interest in this area.In April 2019, Gut convened a round table panel of experts during the European Association for the Study of the Liver International Liver Congress in Vienna to discuss critical and up-to-date issues and clinical trial data regarding ALD, its epidemiology, diagnosis, management, pathomechanisms, possible future treatments and prevention. This paper summarises the discussion and its conclusions.
Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing clinical trials spur scientific interest in this area.In April 2019, Gut convened a round table panel of experts during the European Association for the Study of the Liver International Liver Congress in Vienna to discuss critical and up-to-date issues and clinical trial data regarding ALD, its epidemiology, diagnosis, management, pathomechanisms, possible future treatments and prevention. This paper summarises the discussion and its conclusions.Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing clinical trials spur scientific interest in this area.In April 2019, Gut convened a round table panel of experts during the European Association for the Study of the Liver International Liver Congress in Vienna to discuss critical and up-to-date issues and clinical trial data regarding ALD, its epidemiology, diagnosis, management, pathomechanisms, possible future treatments and prevention. This paper summarises the discussion and its conclusions.
Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing clinical trials spur scientific interest in this area. In April 2019, Gut convened a round table panel of experts during the European Association for the Study of the Liver International Liver Congress in Vienna to discuss critical and up-to-date issues and clinical trial data regarding ALD, its epidemiology, diagnosis, management, pathomechanisms, possible future treatments and prevention. This paper summarises the discussion and its conclusions.
Author Mathurin, Philippe
Zoulim, Fabien
Burra, Patrizia
Cortez-Pinto, Helena
Avila, Matias A
Dufour, Jean-François
Gao, Bin
Thiele, Maja
Gilmore, Ian
Gerbes, Alexander L
Szabo, Gyongyi
Moreno, Christophe
Bataller, Ramon
Schnabl, Bernd
Poznyak, Vladimir
Thursz, Mark R
AuthorAffiliation 12 Department of Mental Health and Substance Abuse, World Health Organization, Geneve, Switzerland
5 Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
3 Liver Centre Munich, Department of Medicine II, University Hospital, LMU Munich, Munich, Germany
9 Liverpool Centre for Alcohol Research, University of Liverpool, Liverpool, UK
6 Multivisceral Transplant Unit, Gastroenterology, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy
14 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
10 Service des Maladies de l’Appareil Digestif, INSERM U795, Hôpital Huriez, Lille, France
15 Department of Gastroenterology and Hepatology, and Department of Clinical Research, Odense University Hospital and University of Southern Denmark, Odense, Denmark
11 Service de Gastroentérologie, Hépatopancréatologie et Oncolog
AuthorAffiliation_xml – name: 12 Department of Mental Health and Substance Abuse, World Health Organization, Geneve, Switzerland
– name: 11 Service de Gastroentérologie, Hépatopancréatologie et Oncologie Digestive, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
– name: 16 Department of Metabolism, Faculty of Medicine, Imperial College, London, UK
– name: 8 Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
– name: 13 Department of Medicine, University of California San Diego, La Jolla, California, USA
– name: 9 Liverpool Centre for Alcohol Research, University of Liverpool, Liverpool, UK
– name: 3 Liver Centre Munich, Department of Medicine II, University Hospital, LMU Munich, Munich, Germany
– name: 15 Department of Gastroenterology and Hepatology, and Department of Clinical Research, Odense University Hospital and University of Southern Denmark, Odense, Denmark
– name: 1 Hepatology, CIBERehd, IdiSNA, CIMA, University of Navarra, Pamplona, Spain
– name: 2 Hepatology, Department of Clinical Research and University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland
– name: 6 Multivisceral Transplant Unit, Gastroenterology, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy
– name: 14 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
– name: 4 Hepatology Department, INSERM U1052, Hospices Civils de Lyon, Cancer Research Centerl of Lyon, University of Lyon, Lyon, France
– name: 10 Service des Maladies de l’Appareil Digestif, INSERM U795, Hôpital Huriez, Lille, France
– name: 7 Departamento de Gastroenterologia, CHLN, Laboratorio de Nutriçao, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
– name: 5 Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Author_xml – sequence: 1
  givenname: Matias A
  orcidid: 0000-0001-6570-3557
  surname: Avila
  fullname: Avila, Matias A
  email: maavila@unav.es
  organization: Hepatology, CIBERehd, IdiSNA, CIMA, University of Navarra, Pamplona, Spain
– sequence: 2
  givenname: Jean-François
  orcidid: 0000-0002-8062-1346
  surname: Dufour
  fullname: Dufour, Jean-François
  organization: Hepatology, Department of Clinical Research and University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland
– sequence: 3
  givenname: Alexander L
  surname: Gerbes
  fullname: Gerbes, Alexander L
  organization: Liver Centre Munich, Department of Medicine II, University Hospital, LMU Munich, Munich, Germany
– sequence: 4
  givenname: Fabien
  orcidid: 0000-0002-2245-0083
  surname: Zoulim
  fullname: Zoulim, Fabien
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– sequence: 5
  givenname: Ramon
  surname: Bataller
  fullname: Bataller, Ramon
  organization: Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
– sequence: 6
  givenname: Patrizia
  surname: Burra
  fullname: Burra, Patrizia
  organization: Multivisceral Transplant Unit, Gastroenterology, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy
– sequence: 7
  givenname: Helena
  surname: Cortez-Pinto
  fullname: Cortez-Pinto, Helena
  organization: Departamento de Gastroenterologia, CHLN, Laboratorio de Nutriçao, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
– sequence: 8
  givenname: Bin
  surname: Gao
  fullname: Gao, Bin
  organization: Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
– sequence: 9
  givenname: Ian
  surname: Gilmore
  fullname: Gilmore, Ian
  organization: Liverpool Centre for Alcohol Research, University of Liverpool, Liverpool, UK
– sequence: 10
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– sequence: 11
  givenname: Christophe
  surname: Moreno
  fullname: Moreno, Christophe
  organization: Service de Gastroentérologie, Hépatopancréatologie et Oncologie Digestive, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
– sequence: 12
  givenname: Vladimir
  surname: Poznyak
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  organization: Department of Mental Health and Substance Abuse, World Health Organization, Geneve, Switzerland
– sequence: 13
  givenname: Bernd
  surname: Schnabl
  fullname: Schnabl, Bernd
  organization: Department of Medicine, University of California San Diego, La Jolla, California, USA
– sequence: 14
  givenname: Gyongyi
  orcidid: 0000-0003-0836-2527
  surname: Szabo
  fullname: Szabo, Gyongyi
  organization: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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  givenname: Maja
  surname: Thiele
  fullname: Thiele, Maja
  organization: Department of Gastroenterology and Hepatology, and Department of Clinical Research, Odense University Hospital and University of Southern Denmark, Odense, Denmark
– sequence: 16
  givenname: Mark R
  surname: Thursz
  fullname: Thursz, Mark R
  organization: Department of Metabolism, Faculty of Medicine, Imperial College, London, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31879281$$D View this record in MEDLINE/PubMed
https://hal.science/hal-03932559$$DView record in HAL
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Issue 4
Keywords alcohol
alcoholic liver disease
fibrosis
cirrhosis
liver transplantation
Language English
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PMCID: PMC7236084
Twitter Jean-François Dufour @dufour_jf
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2020051308113021000_69.4.764.164
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2020051308113021000_69.4.764.162
2020051308113021000_69.4.764.161
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Nguyen-Khac (2020051308113021000_69.4.764.48) 2018; 3
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2020051308113021000_69.4.764.35
2020051308113021000_69.4.764.36
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2020051308113021000_69.4.764.39
Bissonnette (2020051308113021000_69.4.764.55) 2017; 66
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2020051308113021000_69.4.764.30
2020051308113021000_69.4.764.31
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2020051308113021000_69.4.764.32
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2020051308113021000_69.4.764.153
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2020051308113021000_69.4.764.152
2020051308113021000_69.4.764.151
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2020051308113021000_69.4.764.156
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2020051308113021000_69.4.764.158
2020051308113021000_69.4.764.22
2020051308113021000_69.4.764.23
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2020051308113021000_69.4.764.27
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2020051308113021000_69.4.764.145
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2020051308113021000_69.4.764.138
2020051308113021000_69.4.764.137
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2020051308113021000_69.4.764.69
2020051308113021000_69.4.764.118
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2020051308113021000_69.4.764.60
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2020051308113021000_69.4.764.62
2020051308113021000_69.4.764.63
2020051308113021000_69.4.764.64
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2020051308113021000_69.4.764.19
2020051308113021000_69.4.764.102
2020051308113021000_69.4.764.101
2020051308113021000_69.4.764.100
2020051308113021000_69.4.764.106
Forrest (2020051308113021000_69.4.764.71) 2018; 69
Varma (2020051308113021000_69.4.764.80) 2010; 16
2020051308113021000_69.4.764.105
2020051308113021000_69.4.764.104
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2020051308113021000_69.4.764.99
2020051308113021000_69.4.764.12
2020051308113021000_69.4.764.109
2020051308113021000_69.4.764.13
2020051308113021000_69.4.764.108
2020051308113021000_69.4.764.14
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2020051308113021000_69.4.764.17
2020051308113021000_69.4.764.18
2020051308113021000_69.4.764.91
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2020051308113021000_69.4.764.93
2020051308113021000_69.4.764.95
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2020051308113021000_69.4.764.97
2020051308113021000_69.4.764.98
Szabo (2020051308113021000_69.4.764.132) 2017; 52
Thursz (2020051308113021000_69.4.764.85) 2018; 24
Conejo (2020051308113021000_69.4.764.59) 2016; 36
Grucza (2020051308113021000_69.4.764.38) 2006; 29
Chang (2020051308113021000_69.4.764.94) 2015; 62
Sujan (2020051308113021000_69.4.764.57) 2018; 24
Addolorato (2020051308113021000_69.4.764.76) 2016; 100
Sanz-Garcia (2020051308113021000_69.4.764.90) 2019; 70
2020051308113021000_69.4.764.88
2020051308113021000_69.4.764.89
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2020051308113021000_69.4.764.6
2020051308113021000_69.4.764.4
2020051308113021000_69.4.764.82
2020051308113021000_69.4.764.2
2020051308113021000_69.4.764.84
2020051308113021000_69.4.764.1
33972357 - Gut. 2022 Apr;71(4):842-844. doi: 10.1136/gutjnl-2021-324727.
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  article-title: Non-Invasive diagnosis of liver fibrosis in patients with alcohol-related liver disease by transient elastography: an individual patient data meta-analysis
  publication-title: Lancet Gastroenterol Hepatol
  doi: 10.1016/S2468-1253(18)30124-9
– ident: 2020051308113021000_69.4.764.79
  doi: 10.1016/j.jhep.2012.04.004
– reference: 33972357 - Gut. 2022 Apr;71(4):842-844. doi: 10.1136/gutjnl-2021-324727.
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Snippet Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease...
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ Alcohol-related liver disease (ALD), which includes...
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StartPage 764
SubjectTerms Age
Alcohol
Alcohol use
Alcoholic liver disease
Cancer
Chronic illnesses
Cirrhosis
Clinical trials
Epidemiology
Fibrosis
Hepatitis
Humans
Inflammation
Life Sciences
Liver cancer
Liver cirrhosis
Liver diseases
Liver Diseases, Alcoholic - diagnosis
Liver Diseases, Alcoholic - epidemiology
Liver Diseases, Alcoholic - therapy
Liver transplantation
Liver transplants
Metabolism
Metabolites
Mortality
Primary care
Recent advances in clinical practice
Socioeconomic factors
Studies
Title Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting
URI https://gut.bmj.com/content/69/4/764.full
http://hdl.handle.net/10451/56323
https://www.ncbi.nlm.nih.gov/pubmed/31879281
https://www.proquest.com/docview/2372612006
https://www.proquest.com/docview/2331258255
https://hal.science/hal-03932559
https://pubmed.ncbi.nlm.nih.gov/PMC7236084
Volume 69
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