Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of unknown aetiology which leads rapidly to death. As diagnosis of IPF is complex, we aimed to characterise microRNA (miRNA) content of exosomes from sputum of patients with IPF. Using miRNA quantitative PCR arr...
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| Published in | Thorax Vol. 74; no. 3; pp. 309 - 312 |
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| Main Authors | , , , , , , , , |
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BMJ Publishing Group Ltd and British Thoracic Society
01.03.2019
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| Abstract | Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of unknown aetiology which leads rapidly to death. As diagnosis of IPF is complex, we aimed to characterise microRNA (miRNA) content of exosomes from sputum of patients with IPF. Using miRNA quantitative PCR array, we found a substantial dysregulation of sputum exosomal miRNA levels between patients with IPF and healthy subjects and identified a unique signature of three miRNAs. Interestingly, we found a negative correlation between miR-142-3p and diffusing capacity of the lungs for carbon monoxide/alveolar volume. This is the first characterisation of miRNA content of sputum-derived exosomes in IPF that identified promising biomarkers for diagnosis and disease severity. |
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| AbstractList | Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of unknown aetiology which leads rapidly to death. As diagnosis of IPF is complex, we aimed to characterise microRNA (miRNA) content of exosomes from sputum of patients with IPF. Using miRNA quantitative PCR array, we found a substantial dysregulation of sputum exosomal miRNA levels between patients with IPF and healthy subjects and identified a unique signature of three miRNAs. Interestingly, we found a negative correlation between miR-142-3p and diffusing capacity of the lungs for carbon monoxide/alveolar volume. This is the first characterisation of miRNA content of sputum-derived exosomes in IPF that identified promising biomarkers for diagnosis and disease severity. Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of unknown aetiology which leads rapidly to death. As diagnosis of IPF is complex, we aimed to characterise microRNA (miRNA) content of exosomes from sputum of patients with IPF. Using miRNA quantitative PCR array, we found a substantial dysregulation of sputum exosomal miRNA levels between patients with IPF and healthy subjects and identified a unique signature of three miRNAs. Interestingly, we found a negative correlation between miR-142-3p and diffusing capacity of the lungs for carbon monoxide/alveolar volume. This is the first characterisation of miRNA content of sputum-derived exosomes in IPF that identified promising biomarkers for diagnosis and disease severity.Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of unknown aetiology which leads rapidly to death. As diagnosis of IPF is complex, we aimed to characterise microRNA (miRNA) content of exosomes from sputum of patients with IPF. Using miRNA quantitative PCR array, we found a substantial dysregulation of sputum exosomal miRNA levels between patients with IPF and healthy subjects and identified a unique signature of three miRNAs. Interestingly, we found a negative correlation between miR-142-3p and diffusing capacity of the lungs for carbon monoxide/alveolar volume. This is the first characterisation of miRNA content of sputum-derived exosomes in IPF that identified promising biomarkers for diagnosis and disease severity. |
| Author | Guiot, Julien Dequiedt, Franck Thiry, Marc Henket, Monique A Louis, Renaud E Struman, Ingrid Njock, Makon-Sébastien Nivelles, Olivier Corhay, Jean-Louis |
| AuthorAffiliation | 3 Laboratory of Pneumology, GIGA-I3 , University of Liège , Liège , Belgium 2 Pneumology Department , CHU Liège , Liège , Belgium 1 Laboratory of Molecular Angiogenesis, GIGA-R , University of Liège , Liège , Belgium 4 Laboratoire de Biologie Cellulaire et Tissulaire, GIGA-R , University of Liège , Liège , Belgium 5 Laboratoire de Signalisation et Interactions des Protéines, GIGA-R , University of Liège , Liège , Belgium |
| AuthorAffiliation_xml | – name: 5 Laboratoire de Signalisation et Interactions des Protéines, GIGA-R , University of Liège , Liège , Belgium – name: 1 Laboratory of Molecular Angiogenesis, GIGA-R , University of Liège , Liège , Belgium – name: 4 Laboratoire de Biologie Cellulaire et Tissulaire, GIGA-R , University of Liège , Liège , Belgium – name: 2 Pneumology Department , CHU Liège , Liège , Belgium – name: 3 Laboratory of Pneumology, GIGA-I3 , University of Liège , Liège , Belgium |
| Author_xml | – sequence: 1 givenname: Makon-Sébastien orcidid: 0000-0001-8137-1978 surname: Njock fullname: Njock, Makon-Sébastien organization: Laboratory of Molecular Angiogenesis, GIGA-R, University of Liège, Liège, Belgium – sequence: 2 givenname: Julien surname: Guiot fullname: Guiot, Julien organization: Laboratory of Pneumology, GIGA-I3, University of Liège, Liège, Belgium – sequence: 3 givenname: Monique A surname: Henket fullname: Henket, Monique A organization: Laboratory of Pneumology, GIGA-I3, University of Liège, Liège, Belgium – sequence: 4 givenname: Olivier surname: Nivelles fullname: Nivelles, Olivier organization: Laboratory of Molecular Angiogenesis, GIGA-R, University of Liège, Liège, Belgium – sequence: 5 givenname: Marc surname: Thiry fullname: Thiry, Marc organization: Laboratoire de Biologie Cellulaire et Tissulaire, GIGA-R, University of Liège, Liège, Belgium – sequence: 6 givenname: Franck surname: Dequiedt fullname: Dequiedt, Franck organization: Laboratoire de Signalisation et Interactions des Protéines, GIGA-R, University of Liège, Liège, Belgium – sequence: 7 givenname: Jean-Louis surname: Corhay fullname: Corhay, Jean-Louis organization: Laboratory of Pneumology, GIGA-I3, University of Liège, Liège, Belgium – sequence: 8 givenname: Renaud E surname: Louis fullname: Louis, Renaud E organization: Laboratory of Pneumology, GIGA-I3, University of Liège, Liège, Belgium – sequence: 9 givenname: Ingrid surname: Struman fullname: Struman, Ingrid organization: Laboratory of Molecular Angiogenesis, GIGA-R, University of Liège, Liège, Belgium |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30244194$$D View this record in MEDLINE/PubMed |
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| Keywords | interstitial fibrosis idiopathic pulmonary fibrosis |
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| References | Guiot, Henket, Corhay (R3) 2017; 12 Gallo, Tandon, Alevizos (R4) 2012; 7 Huang, Sun, Zhao (R10) 2015; 1 Guiot, Moermans, Henket (R2) 2017; 195 Njock, Fish (R6) 2017; 28 Pandit, Corcoran, Yousef (R9) 2010; 182 Carraro, Shrestha, Rostkovius (R8) 2014; 141 Admyre, Grunewald, Thyberg (R5) 2003; 22 Raghu (R1) 2011; 37 Sánchez-Vidaurre, Eldh, Larssen (R7) 2017; 140 Huang, Sun, Zhao 2015; 1 Sánchez-Vidaurre, Eldh, Larssen 2017; 140 Raghu 2011; 37 Njock, Fish 2017; 28 Pandit, Corcoran, Yousef 2010; 182 Guiot, Moermans, Henket 2017; 195 Admyre, Grunewald, Thyberg 2003; 22 Guiot, Henket, Corhay 2017; 12 Gallo, Tandon, Alevizos 2012; 7 Carraro, Shrestha, Rostkovius 2014; 141 2020050723472329000_74.3.309.1 Guiot (2020050723472329000_74.3.309.2) 2017; 195 2020050723472329000_74.3.309.9 Sánchez-Vidaurre (2020050723472329000_74.3.309.7) 2017; 140 2020050723472329000_74.3.309.8 2020050723472329000_74.3.309.5 2020050723472329000_74.3.309.3 2020050723472329000_74.3.309.10 2020050723472329000_74.3.309.4 Njock (2020050723472329000_74.3.309.6) 2017; 28 |
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| Snippet | Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of unknown aetiology which leads rapidly to death. As diagnosis of IPF... |
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| SubjectTerms | Age Ambulatory care Biochemistry, biophysics & molecular biology Biochimie, biophysique & biologie moléculaire Biomarkers Biomarkers - metabolism Brief Communication Case-Control Studies Cytochrome Disease Exosomes - metabolism Experiments Female Gene expression Humans idiopathic pulmonary fibrosis Idiopathic Pulmonary Fibrosis - diagnosis Idiopathic Pulmonary Fibrosis - etiology Idiopathic Pulmonary Fibrosis - metabolism interstitial fibrosis Life sciences Male MicroRNAs MicroRNAs - metabolism Patients Principal components analysis Pulmonary fibrosis Sciences du vivant Sensitivity and Specificity Sputum - metabolism Studies |
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| Title | Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis |
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