Enterovirus related metabolic myopathy: a postviral fatigue syndrome

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 74; no. 10; pp. 1382 - 1386
• Main Authors: Lane, R J M, Soteriou, B A, Zhang, H, Archard, L C
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.10.2003; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Adult; Anaerobic threshold; Biological and medical sciences; Biopsy; Causes of; CFS; Chronic fatigue syndrome; Diseases of striated muscles. Neuromuscular diseases; DNA, Viral - analysis; Enterovirus - genetics; Enterovirus - pathogenicity; Enterovirus B, Human - genetics; Enterovirus B, Human - pathogenicity; enterovirus RNA sequences; Enteroviruses; Exercise; Exercise - physiology; Exercise Test; Fatigue Syndrome, Chronic - etiology; Fatigue Syndrome, Chronic - virology; Female; Humans; Infections; Influence; Laboratories; Lactic acid; Lactic Acid - metabolism; Male; Medical sciences; Middle Aged; Muscle diseases; muscle energy metabolism; Muscle, Skeletal - pathology; Muscle, Skeletal - physiology; Muscle, Skeletal - virology; Muscular Diseases - metabolism; Muscular Diseases - virology; Myocarditis; nested polymerase chain reaction; Neurology; Physical Endurance; Physiological aspects; Polymerase chain reaction; postviral fatigue syndrome; Reverse Transcriptase Polymerase Chain Reaction; reverse transcription; RT-NPCR; SATET; subanaerobic threshold exercise test; Viral infections; Viruses; United Kingdom; United Kingdom > UK; Physical exercise; Human; Energy metabolism; Pathophysiology; RNA; Picornaviridae; Pathogenesis; Enterovirus; Chronic fatigue syndrome; Virus; Lactates; Striated muscle disease; Quadriceps muscle
• ISSN: 0022-3050; 1468-330X
• DOI: 10.1136/jnnp.74.10.1382

Objective: To detect and characterise enterovirus RNA in skeletal muscle from patients with chronic fatigue syndrome (CFS) and to compare efficiency of muscle energy metabolism in enterovirus positive and negative CFS patients. Methods: Quadriceps muscle biopsy samples from 48 patients with CFS were...