Lupus-associated atypical memory B cells are mTORC1-hyperactivated and functionally dysregulated - Wu, Chunmei; Fu, Qiong; Guo, Qiang; Chen, Sheng; Goswami, Shyamal; Sun, Shuhui; Li, Teng; Cao, Xingjian; Chu, Fuying; Chen, Zechuan; Liu, Mei; Liu, Yuanhua; et al. (Annals of the rheumatic diseases, 2019)
Keywords: Adult; Antibodies; Apoptosis; Arthritis; B cells; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; Biomarkers; Biopsy, Needle; Cell activation; Cell differentiation; Cell Differentiation - genetics; Cohort Studies; Cytokines; Disease; Endocytosis; Enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - methods; Female; Flow cytometry; Flow Cytometry - methods; Gene expression; Hepatitis; Humans; Hypoxia; Immunoglobulins; Immunohistochemistry; Immunological memory; Inflammation; Lipid metabolism; Lupus; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - pathology; Lupus nephritis; Lupus Nephritis - genetics; Lupus Nephritis - pathology; Lymphocytes; Lymphocytes B; Lymphocytes T; Male; Mechanistic Target of Rapamycin Complex 1 - genetics; Mechanistic Target of Rapamycin Complex 1 - metabolism; Memory cells; Metabolism; Middle Aged; Nephritis; Patients; Phenotypes; Population; Population studies; Prognosis; Quorum sensing; Rapamycin; Ribonucleic acid; RNA; Sensitivity and Specificity; Signal transduction; Signal Transduction - genetics; Systemic Lupus Erythematosus; TOR protein; Transcription factors; Up-Regulation; Viral infections; China; systemic lupus erythematosus; cytokines; B cells