Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune response

• Published in: Journal for immunotherapy of cancer Vol. 8; no. 1; p. e000617
• Main Authors: Roelands, Jessica, Hendrickx, Wouter, Zoppoli, Gabriele, Mall, Raghvendra, Saad, Mohamad, Halliwill, Kyle, Curigliano, Giuseppe, Rinchai, Darawan, Decock, Julie, Delogu, Lucia G, Turan, Tolga, Samayoa, Josue, Chouchane, Lotfi, Ballestrero, Alberto, Wang, Ena, Finetti, Pascal, Bertucci, Francois, Miller, Lance D, Galon, Jerome, Marincola, Francesco M, Kuppen, Peter J K, Ceccarelli, Michele, Bedognetti, Davide
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.04.2020; BMJ Publishing Group
• Subjects: Breast cancer; Cancer; Classification; Clustering; Data analysis; Datasets; Female; Gene expression; Gene Expression Profiling - methods; Humans; Immunity - immunology; Immunology; Immunotherapy; Immunotherapy - methods; Immunotherapy Biomarkers; Life Sciences; Male; Melanoma; Metastasis; Mutation; Neoplasms - immunology; Neoplasms - mortality; Oncogenes - immunology; Prognosis; Survival Analysis; Tumors; genome Instability; gene expression profiling; genetic markers; immunotherapy; cytotoxicity, immunologic

BackgroundAn immune active cancer phenotype typified by a T helper 1 (Th-1) immune response has been associated with increased responsiveness to immunotherapy and favorable prognosis in some but not all cancer types. The reason of this differential prognostic connotation remains unknown.MethodsTo ex...