The Role of immune and inflammatory mechanisms in ALS

• Published in: Current molecular medicine Vol. 11; no. 3; p. 246
• Main Authors: McCombe, P A, Henderson, R D
• Format: Journal Article
• Language: English
• Published: Netherlands 01.04.2011
• Subjects: Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - immunology; Amyotrophic Lateral Sclerosis - pathology; CD4-Positive T-Lymphocytes; Central Nervous System - immunology; Central Nervous System - injuries; Central Nervous System - pathology; Humans; Inflammation - immunology; Mutation; Occupational Exposure - adverse effects; Superoxide Dismutase - genetics; Superoxide Dismutase-1

Amyotrophic lateral sclerosis (ALS) is a severe progressive neurodegenerative disease. The cause is unknown, but genetic abnormalities have been identified in subjects with familial ALS and also in subjects with sporadic ALS. Environmental factors such as occupational exposure have been shown to be...