ST3Gal.I sialyltransferase relevance in bladder cancer tissues and cell lines

• Published in: BMC cancer Vol. 9; no. 1; p. 357
• Main Authors: Videira, Paula A, Correia, Manuela, Malagolini, Nadia, Crespo, Hélio J, Ligeiro, Dário, Calais, Fernando M, Trindade, Helder, Dall'Olio, Fabio
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07.10.2009; BioMed Central; BMC
• Subjects: Aged; Aged, 80 and over; Antigen receptors, T cell; Antigens, Viral, Tumor - metabolism; Bladder cancer; Cell Line, Tumor; Development and progression; Female; Gene expression; Gene Expression Regulation, Neoplastic; Genetic aspects; Humans; Male; Middle Aged; Neoplasm Staging; Physiological aspects; Receptors; Sialyltransferases - genetics; Sialyltransferases - metabolism; T cells; Urinary Bladder Neoplasms - enzymology; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; Italy; Portugal

The T antigen is a tumor-associated structure whose sialylated form (the sialyl-T antigen) involves the altered expression of sialyltransferases and has been related with worse prognosis. Since little or no information is available on this subject, we investigated the regulation of the sialyltransfe...