Evolution of a cluster of innate immune genes (β-defensins) along the ancestral lines of chicken and zebra finch
Avian beta-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work identified 14 AvBDs in a cluster on chromosome three. The release of a second bird genome, the zebra finch, allows us to study the comparative evolutionar...
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| Published in | Immunome research Vol. 6; no. 1; p. 3 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
BioMed Central Ltd
01.04.2010
BioMed Central |
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| Abstract | Avian beta-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work identified 14 AvBDs in a cluster on chromosome three. The release of a second bird genome, the zebra finch, allows us to study the comparative evolutionary history of these gene clusters between from two species that shared a common ancestor about 100 million years ago.
A phylogenetic analysis of the beta-defensin gene clusters in the chicken and the zebra finch identified several cases of gene duplication and gene loss along their ancestral lines. In the zebra finch genome a cluster of 22 AvBD genes were identified, all located within 125 Kbp on chromosome three. Ten of the 22 genes were found to be highly conserved with orthologous genes in the chicken genome. The remaining 12 genes were all located within a cluster of 58 Kbp and are suggested to be a result of recent gene duplication events that occurred after the galliformes- passeriformes split (G-P split). Within the chicken genome, AvBD6 was found to be a duplication of AvBD7, whereas the gene AvDB14 seems to have been lost along the ancestral line of the zebra finch. The duplicated beta-defensin genes have had a significantly higher accumulation of non-synonymous over synonymous substitutions compared to the genes that have not undergone duplication since the G-P split. The expression patterns of avian beta-defensin genes seem to be well conserved between chicken and zebra finch.
The genomic comparisons of the beta-defensins gene clusters of the chicken and zebra finch illuminate the evolutionary history of this gene complex. Along their ancestral lines, several gene duplication events have occurred in the passerine line after the galliformes-passeriformes split giving rise to 12 novel genes compared to a single duplication event in the galliformes line. After the duplication events, the duplicated genes have been subject to a relaxed selection pressure compared to the non-duplicated genes, thus supporting models of evolution by gene duplication. |
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| AbstractList | BACKGROUND: Avian beta-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work identified 14 AvBDs in a cluster on chromosome three. The release of a second bird genome, the zebra finch, allows us to study the comparative evolutionary history of these gene clusters between from two species that shared a common ancestor about 100 million years ago.RESULTS: A phylogenetic analysis of the beta-defensin gene clusters in the chicken and the zebra finch identified several cases of gene duplication and gene loss along their ancestral lines. In the zebra finch genome a cluster of 22 AvBD genes were identified, all located within 125 Kbp on chromosome three. Ten of the 22 genes were found to be highly conserved with orthologous genes in the chicken genome. The remaining 12 genes were all located within a cluster of 58 Kbp and are suggested to be a result of recent gene duplication events that occurred after the galliformes- passeriformes split (G-P split). Within the chicken genome, AvBD6 was found to be a duplication of AvBD7, whereas the gene AvDB14 seems to have been lost along the ancestral line of the zebra finch. The duplicated beta-defensin genes have had a significantly higher accumulation of non-synonymous over synonymous substitutions compared to the genes that have not undergone duplication since the G-P split. The expression patterns of avian beta-defensin genes seem to be well conserved between chicken and zebra finch.CONCLUSION: The genomic comparisons of the beta-defensins gene clusters of the chicken and zebra finch illuminate the evolutionary history of this gene complex. Along their ancestral lines, several gene duplication events have occurred in the passerine line after the galliformes-passeriformes split giving rise to 12 novel genes compared to a single duplication event in the galliformes line. After the duplication events, the duplicated genes have been subject to a relaxed selection pressure compared to the non-duplicated genes, thus supporting models of evolution by gene duplication. BACKGROUND: Avian β-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work identified 14 AvBDs in a cluster on chromosome three. The release of a second bird genome, the zebra finch, allows us to study the comparative evolutionary history of these gene clusters between from two species that shared a common ancestor about 100 million years ago. RESULTS: A phylogenetic analysis of the β-defensin gene clusters in the chicken and the zebra finch identified several cases of gene duplication and gene loss along their ancestral lines. In the zebra finch genome a cluster of 22 AvBD genes were identified, all located within 125 Kbp on chromosome three. Ten of the 22 genes were found to be highly conserved with orthologous genes in the chicken genome. The remaining 12 genes were all located within a cluster of 58 Kbp and are suggested to be a result of recent gene duplication events that occurred after the galliformes- passeriformes split (G-P split). Within the chicken genome, AvBD6 was found to be a duplication of AvBD7, whereas the gene AvDB14 seems to have been lost along the ancestral line of the zebra finch. The duplicated β-defensin genes have had a significantly higher accumulation of non-synonymous over synonymous substitutions compared to the genes that have not undergone duplication since the G-P split. The expression patterns of avian β-defensin genes seem to be well conserved between chicken and zebra finch. CONCLUSION: The genomic comparisons of the β-defensins gene clusters of the chicken and zebra finch illuminate the evolutionary history of this gene complex. Along their ancestral lines, several gene duplication events have occurred in the passerine line after the galliformes-passeriformes split giving rise to 12 novel genes compared to a single duplication event in the galliformes line. After the duplication events, the duplicated genes have been subject to a relaxed selection pressure compared to the non-duplicated genes, thus supporting models of evolution by gene duplication. Avian beta-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work identified 14 AvBDs in a cluster on chromosome three. The release of a second bird genome, the zebra finch, allows us to study the comparative evolutionary history of these gene clusters between from two species that shared a common ancestor about 100 million years ago.BACKGROUNDAvian beta-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work identified 14 AvBDs in a cluster on chromosome three. The release of a second bird genome, the zebra finch, allows us to study the comparative evolutionary history of these gene clusters between from two species that shared a common ancestor about 100 million years ago.A phylogenetic analysis of the beta-defensin gene clusters in the chicken and the zebra finch identified several cases of gene duplication and gene loss along their ancestral lines. In the zebra finch genome a cluster of 22 AvBD genes were identified, all located within 125 Kbp on chromosome three. Ten of the 22 genes were found to be highly conserved with orthologous genes in the chicken genome. The remaining 12 genes were all located within a cluster of 58 Kbp and are suggested to be a result of recent gene duplication events that occurred after the galliformes- passeriformes split (G-P split). Within the chicken genome, AvBD6 was found to be a duplication of AvBD7, whereas the gene AvDB14 seems to have been lost along the ancestral line of the zebra finch. The duplicated beta-defensin genes have had a significantly higher accumulation of non-synonymous over synonymous substitutions compared to the genes that have not undergone duplication since the G-P split. The expression patterns of avian beta-defensin genes seem to be well conserved between chicken and zebra finch.RESULTSA phylogenetic analysis of the beta-defensin gene clusters in the chicken and the zebra finch identified several cases of gene duplication and gene loss along their ancestral lines. In the zebra finch genome a cluster of 22 AvBD genes were identified, all located within 125 Kbp on chromosome three. Ten of the 22 genes were found to be highly conserved with orthologous genes in the chicken genome. The remaining 12 genes were all located within a cluster of 58 Kbp and are suggested to be a result of recent gene duplication events that occurred after the galliformes- passeriformes split (G-P split). Within the chicken genome, AvBD6 was found to be a duplication of AvBD7, whereas the gene AvDB14 seems to have been lost along the ancestral line of the zebra finch. The duplicated beta-defensin genes have had a significantly higher accumulation of non-synonymous over synonymous substitutions compared to the genes that have not undergone duplication since the G-P split. The expression patterns of avian beta-defensin genes seem to be well conserved between chicken and zebra finch.The genomic comparisons of the beta-defensins gene clusters of the chicken and zebra finch illuminate the evolutionary history of this gene complex. Along their ancestral lines, several gene duplication events have occurred in the passerine line after the galliformes-passeriformes split giving rise to 12 novel genes compared to a single duplication event in the galliformes line. After the duplication events, the duplicated genes have been subject to a relaxed selection pressure compared to the non-duplicated genes, thus supporting models of evolution by gene duplication.CONCLUSIONThe genomic comparisons of the beta-defensins gene clusters of the chicken and zebra finch illuminate the evolutionary history of this gene complex. Along their ancestral lines, several gene duplication events have occurred in the passerine line after the galliformes-passeriformes split giving rise to 12 novel genes compared to a single duplication event in the galliformes line. After the duplication events, the duplicated genes have been subject to a relaxed selection pressure compared to the non-duplicated genes, thus supporting models of evolution by gene duplication. Avian beta-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work identified 14 AvBDs in a cluster on chromosome three. The release of a second bird genome, the zebra finch, allows us to study the comparative evolutionary history of these gene clusters between from two species that shared a common ancestor about 100 million years ago. A phylogenetic analysis of the beta-defensin gene clusters in the chicken and the zebra finch identified several cases of gene duplication and gene loss along their ancestral lines. In the zebra finch genome a cluster of 22 AvBD genes were identified, all located within 125 Kbp on chromosome three. Ten of the 22 genes were found to be highly conserved with orthologous genes in the chicken genome. The remaining 12 genes were all located within a cluster of 58 Kbp and are suggested to be a result of recent gene duplication events that occurred after the galliformes- passeriformes split (G-P split). Within the chicken genome, AvBD6 was found to be a duplication of AvBD7, whereas the gene AvDB14 seems to have been lost along the ancestral line of the zebra finch. The duplicated beta-defensin genes have had a significantly higher accumulation of non-synonymous over synonymous substitutions compared to the genes that have not undergone duplication since the G-P split. The expression patterns of avian beta-defensin genes seem to be well conserved between chicken and zebra finch. The genomic comparisons of the beta-defensins gene clusters of the chicken and zebra finch illuminate the evolutionary history of this gene complex. Along their ancestral lines, several gene duplication events have occurred in the passerine line after the galliformes-passeriformes split giving rise to 12 novel genes compared to a single duplication event in the galliformes line. After the duplication events, the duplicated genes have been subject to a relaxed selection pressure compared to the non-duplicated genes, thus supporting models of evolution by gene duplication. Avian [beta]-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work identified 14 AvBDs in a cluster on chromosome three. The release of a second bird genome, the zebra finch, allows us to study the comparative evolutionary history of these gene clusters between from two species that shared a common ancestor about 100 million years ago. A phylogenetic analysis of the [beta]-defensin gene clusters in the chicken and the zebra finch identified several cases of gene duplication and gene loss along their ancestral lines. In the zebra finch genome a cluster of 22 AvBD genes were identified, all located within 125 Kbp on chromosome three. Ten of the 22 genes were found to be highly conserved with orthologous genes in the chicken genome. The remaining 12 genes were all located within a cluster of 58 Kbp and are suggested to be a result of recent gene duplication events that occurred after the galliformes- passeriformes split (G-P split). Within the chicken genome, AvBD6 was found to be a duplication of AvBD7, whereas the gene AvDB14 seems to have been lost along the ancestral line of the zebra finch. The duplicated [beta]-defensin genes have had a significantly higher accumulation of non-synonymous over synonymous substitutions compared to the genes that have not undergone duplication since the G-P split. The expression patterns of avian [beta]-defensin genes seem to be well conserved between chicken and zebra finch. The genomic comparisons of the [beta]-defensins gene clusters of the chicken and zebra finch illuminate the evolutionary history of this gene complex. Along their ancestral lines, several gene duplication events have occurred in the passerine line after the galliformes-passeriformes split giving rise to 12 novel genes compared to a single duplication event in the galliformes line. After the duplication events, the duplicated genes have been subject to a relaxed selection pressure compared to the non-duplicated genes, thus supporting models of evolution by gene duplication. BACKGROUND:Avian beta-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work identified 14 AvBDs in a cluster on chromosome three. The release of a second bird genome, the zebra finch, allows us to study the comparative evolutionary history of these gene clusters between from two species that shared a common ancestor about 100 million years ago. RESULTS:A phylogenetic analysis of the beta-defensin gene clusters in the chicken and the zebra finch identified several cases of gene duplication and gene loss along their ancestral lines. In the zebra finch genome a cluster of 22 AvBD genes were identified, all located within 125Kbp on chromosome three. Ten of the 22 genes were found to be highly conserved with orthologous genes in the chicken genome. The remaining 12 genes were all located within a cluster of 58 Kbp and are suggested to be a result of recent gene duplication events that occurred after the galliformes- passeriformes split (G-P split) and where no duplications have happened along the chicken line. Within the chicken genome, AvBD6 was found to be a duplication of AvBD7, whereas the gene AvDB14 seems to have been lost along the ancestral line of the zebra finch. The duplicated beta-defensin genes have had a significantly higher accumulation of non-synonymous over synonymous substitutions compared to the genes that have not undergone duplication since the G-P split. The expression patterns of avian beta-defensin genes seem to be well conserved between chicken and zebra finch.CONCLUSION:The genomic comparisons of the beta-defensins gene clusters of the chicken and zebra finch illuminate the evolutionary history of this gene complex. Along their ancestral lines, several gene duplication events have occurred in the passerine line after the galliformes-passeriformes split giving rise to 12 novel genes compared to a single duplication event in the galliformes line. After the duplication events, the duplicated genes have been subject to a relaxed selection pressure compared to the non-duplicated genes, thus supporting models of evolution by gene duplication. |
| Audience | Academic |
| Author | Ekblom, Robert Hellgren, Olof |
| AuthorAffiliation | 4 Department of Population Biology and Conservation Biology, Uppsala University, SE-75226 Uppsala, Sweden 2 Department of Animal Ecology, Lund University, SE-22362, Lund, Sweden 3 Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield S10 2TN, UK 1 Edward Grey Institute, Department of Zoology, South Parks Road, Oxford, OX1 3PS, UK |
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| Author_xml | – sequence: 1 givenname: Olof surname: Hellgren fullname: Hellgren, Olof – sequence: 2 givenname: Robert surname: Ekblom fullname: Ekblom, Robert |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20359324$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206864$$DView record from Swedish Publication Index https://lup.lub.lu.se/record/141a8aad-bdae-4649-b0a9-62ecd5bad53e$$DView record from Swedish Publication Index oai:portal.research.lu.se:publications/141a8aad-bdae-4649-b0a9-62ecd5bad53e$$DView record from Swedish Publication Index |
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| Copyright | COPYRIGHT 2010 BioMed Central Ltd. Copyright ©2010 Hellgren and Ekblom; licensee BioMed Central Ltd. 2010 Hellgren and Ekblom; licensee BioMed Central Ltd. |
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| CorporateAuthor | Molecular Ecology and Evolution Lab Department of Biology Molekylär ekologi och evolution Biologiska institutionen Forskargrupper vid Biologiska institutionen Lunds universitet Naturvetenskapliga fakulteten MEMEG Faculty of Science Lund University Research groups at the Department of Biology |
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| References | 8029240 - Proc Biol Sci. 1994 May 23;256(1346):119-24 14963090 - Mol Biol Evol. 2004 May;21(5):819-27 12912839 - Bioinformatics. 2003 Aug 12;19(12):1572-4 18266620 - Mol Ecol. 2008 Apr;17(7):1636-47 18171149 - Am Nat. 2008 Jan;171(1):35-43 19732743 - Biochem Biophys Res Commun. 2009 Nov 20;389(3):443-8 12716986 - Mol Biol Evol. 2003 Jun;20(6):914-23 17635867 - Infect Immun. 2007 Oct;75(10):4780-91 16157672 - Genetics. 2005 Dec;171(4):1847-59 17488738 - Mol Biol Evol. 2007 Aug;24(8):1596-9 12734011 - Genome Biol. 2003;4(5):R31 15310403 - BMC Genomics. 2004 Aug 13;5(1):56 12519901 - Mol Biol Evol. 2003 Jan;20(1):18-20 17987029 - Nat Genet. 2007 Dec;39(12):1461-8 12411706 - Science. 2002 Nov 1;298(5595):1025-9 11213266 - Cell Mol Life Sci. 1999 Oct 1;56(1-2):94-103 17938991 - J Mol Evol. 2007 Nov;65(5):605-15 17928853 - Nature. 2007 Oct 11;449(7163):677-81 14769468 - FEMS Microbiol Lett. 2004 Feb 9;231(1):67-71 12493009 - Immunol Rev. 2002 Dec;190:95-122 18493078 - Genetics. 2008 May;179(1):651-67 11129644 - J Leukoc Biol. 2000 Dec;68(6):779-84 17785833 - J Immunol. 2007 Sep 15;179(6):3958-65 17979760 - Curr Protein Pept Sci. 2007 Oct;8(5):446-59 17683638 - Mol Cancer. 2007;6:50 10666704 - Mol Biol Evol. 2000 Jan;17(1):32-43 18415094 - Immunogenetics. 2008 May;60(5):249-56 12916016 - Am J Hum Genet. 2003 Sep;73(3):591-600 12930229 - J Intern Med. 2003 Sep;254(3):197-215 9809615 - J Interferon Cytokine Res. 1998 Oct;18(10):805-16 18313763 - Vet Immunol Immunopathol. 2008 Jul 15;124(1-2):1-18 17467809 - Immunol Lett. 2007 May 15;110(1):86-9 15148642 - Immunogenetics. 2004 Jun;56(3):170-7 17483113 - Mol Biol Evol. 2007 Aug;24(8):1586-91 15381059 - Biochem Biophys Res Commun. 2004 Oct 22;323(3):721-7 16313451 - J Evol Biol. 2005 Nov;18(6):1387-94 17942681 - Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17004-9 12238953 - BMC Infect Dis. 2002 Sep 18;2:20 15219392 - Trends Genet. 2004 Jul;20(7):287-90 18581108 - Immunogenetics. 2008 Sep;60(9):495-506 17705135 - Eur J Immunol. 2007 Sep;37(9):2474-86 15956198 - Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8791-2 17622265 - Heredity (Edinb). 2007 Oct;99(4):364-73 11790538 - Curr Opin Immunol. 2002 Feb;14(1):96-102 15034147 - Nucleic Acids Res. 2004;32(5):1792-7 15388519 - Bioinformatics. 2005 Mar 1;21(5):650-9 16094301 - Heredity (Edinb). 2006 Jan;96(1):7-21 15102787 - Infect Immun. 2004 May;72(5):2772-9 17346671 - Biochem Biophys Res Commun. 2007 Apr 27;356(1):169-74 17483936 - Immunogenetics. 2007 Jul;59(7):573-80 16724099 - Nat Rev Immunol. 2006 Jun;6(6):447-56 17194828 - Antimicrob Agents Chemother. 2007 Mar;51(3):912-22 11158379 - Mol Biol Evol. 2001 Feb;18(2):206-13 16226346 - Peptides. 2006 Apr;27(4):931-40 16714567 - Infect Immun. 2006 Jun;74(6):3375-80 12949495 - Nat Rev Immunol. 2003 Sep;3(9):710-20 18555739 - Curr Opin Microbiol. 2008 Jun;11(3):284-9 |
| References_xml | – reference: 16157672 - Genetics. 2005 Dec;171(4):1847-59 – reference: 19732743 - Biochem Biophys Res Commun. 2009 Nov 20;389(3):443-8 – reference: 12916016 - Am J Hum Genet. 2003 Sep;73(3):591-600 – reference: 18415094 - Immunogenetics. 2008 May;60(5):249-56 – reference: 17635867 - Infect Immun. 2007 Oct;75(10):4780-91 – reference: 17483936 - Immunogenetics. 2007 Jul;59(7):573-80 – reference: 10666704 - Mol Biol Evol. 2000 Jan;17(1):32-43 – reference: 17467809 - Immunol Lett. 2007 May 15;110(1):86-9 – reference: 17683638 - Mol Cancer. 2007;6:50 – reference: 17928853 - Nature. 2007 Oct 11;449(7163):677-81 – reference: 17346671 - Biochem Biophys Res Commun. 2007 Apr 27;356(1):169-74 – reference: 15102787 - Infect Immun. 2004 May;72(5):2772-9 – reference: 9809615 - J Interferon Cytokine Res. 1998 Oct;18(10):805-16 – reference: 17987029 - Nat Genet. 2007 Dec;39(12):1461-8 – reference: 17622265 - Heredity (Edinb). 2007 Oct;99(4):364-73 – reference: 12238953 - BMC Infect Dis. 2002 Sep 18;2:20 – reference: 14963090 - Mol Biol Evol. 2004 May;21(5):819-27 – reference: 18171149 - Am Nat. 2008 Jan;171(1):35-43 – reference: 16714567 - Infect Immun. 2006 Jun;74(6):3375-80 – reference: 15219392 - Trends Genet. 2004 Jul;20(7):287-90 – reference: 17194828 - Antimicrob Agents Chemother. 2007 Mar;51(3):912-22 – reference: 17979760 - Curr Protein Pept Sci. 2007 Oct;8(5):446-59 – reference: 16226346 - Peptides. 2006 Apr;27(4):931-40 – reference: 16724099 - Nat Rev Immunol. 2006 Jun;6(6):447-56 – reference: 12519901 - Mol Biol Evol. 2003 Jan;20(1):18-20 – reference: 18493078 - Genetics. 2008 May;179(1):651-67 – reference: 17483113 - Mol Biol Evol. 2007 Aug;24(8):1586-91 – reference: 17705135 - Eur J Immunol. 2007 Sep;37(9):2474-86 – reference: 12411706 - Science. 2002 Nov 1;298(5595):1025-9 – reference: 8029240 - Proc Biol Sci. 1994 May 23;256(1346):119-24 – reference: 12930229 - J Intern Med. 2003 Sep;254(3):197-215 – reference: 11790538 - Curr Opin Immunol. 2002 Feb;14(1):96-102 – reference: 12734011 - Genome Biol. 2003;4(5):R31 – reference: 12912839 - Bioinformatics. 2003 Aug 12;19(12):1572-4 – reference: 18555739 - Curr Opin Microbiol. 2008 Jun;11(3):284-9 – reference: 14769468 - FEMS Microbiol Lett. 2004 Feb 9;231(1):67-71 – reference: 15310403 - BMC Genomics. 2004 Aug 13;5(1):56 – reference: 12716986 - Mol Biol Evol. 2003 Jun;20(6):914-23 – reference: 15388519 - Bioinformatics. 2005 Mar 1;21(5):650-9 – reference: 11129644 - J Leukoc Biol. 2000 Dec;68(6):779-84 – reference: 12493009 - Immunol Rev. 2002 Dec;190:95-122 – reference: 18581108 - Immunogenetics. 2008 Sep;60(9):495-506 – reference: 17488738 - Mol Biol Evol. 2007 Aug;24(8):1596-9 – reference: 11213266 - Cell Mol Life Sci. 1999 Oct 1;56(1-2):94-103 – reference: 11158379 - Mol Biol Evol. 2001 Feb;18(2):206-13 – reference: 17938991 - J Mol Evol. 2007 Nov;65(5):605-15 – reference: 15956198 - Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8791-2 – reference: 15148642 - Immunogenetics. 2004 Jun;56(3):170-7 – reference: 18266620 - Mol Ecol. 2008 Apr;17(7):1636-47 – reference: 16313451 - J Evol Biol. 2005 Nov;18(6):1387-94 – reference: 16094301 - Heredity (Edinb). 2006 Jan;96(1):7-21 – reference: 15034147 - Nucleic Acids Res. 2004;32(5):1792-7 – reference: 17942681 - Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17004-9 – reference: 17785833 - J Immunol. 2007 Sep 15;179(6):3958-65 – reference: 15381059 - Biochem Biophys Res Commun. 2004 Oct 22;323(3):721-7 – reference: 12949495 - Nat Rev Immunol. 2003 Sep;3(9):710-20 – reference: 18313763 - Vet Immunol Immunopathol. 2008 Jul 15;124(1-2):1-18 |
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| Snippet | Avian beta-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work identified 14... Background Avian [beta]-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work... Avian [beta]-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work identified... BACKGROUND: Avian β-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work... BACKGROUND:Avian beta-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work... BACKGROUND: Avian beta-defensins (AvBDs) represent a group of innate immune genes with broad antimicrobial activity. Within the chicken genome, previous work... |
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| SubjectTerms | Amino acids Analysis Animal genetics Biologi Biological Sciences Evolutionary Biology Evolutionsbiologi Genetics Genetics and Genomics Genetik Genetik och genomik Immunologi Immunology Natural Sciences Naturvetenskap Zebra finch |
| Title | Evolution of a cluster of innate immune genes (β-defensins) along the ancestral lines of chicken and zebra finch |
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