Array-Based Approaches for the Identification of Epigenetic Silenced Tumor Suppressor Genes

• Published in: Current genomics Vol. 9; no. 1; pp. 22 - 24
• Main Authors: Takai, Noriyuki, Narahara, Hisashi
• Format: Journal Article
• Language: English
• Published: United Arab Emirates Bentham Science Publishers Ltd 01.03.2008
• Subjects: DNA methylation; histone modification; epigenetics; Tumor suppressor gene

Carcinogenesis involves the inactivation or inhibition of genes that function as tumor suppressors. Deletions, mutations, or epigenetic silencing of tumor suppressor genes can lead to altered growth, differentiation, and apoptosis. DNA methylation and histone modifications are important epigenetic m...