Epithelial Notch signaling is a limiting step for pancreatic carcinogenesis

• Published in: BMC cancer Vol. 14; no. 1; p. 862
• Main Authors: Thomas, Marsha M, Zhang, Yaqing, Mathew, Esha, Kane, Kevin T, Maillard, Ivan, Pasca di Magliano, Marina
• Format: Journal Article
• Language: English
• Published: England BioMed Central 22.11.2014; BioMed Central Ltd
• Subjects: Animals; Deoxyribonucleic acid; DNA; Epithelium - chemistry; Epithelium - metabolism; Experiments; Female; Male; Medical prognosis; Medical research; Mice; Mice, Transgenic; Molecular biology; Molecular weight; Mortality; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Pancreas - chemistry; Pancreas - metabolism; Pancreatic cancer; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatitis; Receptors, Notch - genetics; Receptors, Notch - metabolism; Rodents; Signal Transduction - genetics; Signal Transduction - physiology; Studies; Transcription Factors - genetics; Transcription Factors - metabolism; Ann Arbor Michigan

Pancreatic cancer is one of the deadliest human malignancies, with few therapeutic options. Re-activation of embryonic signaling pathways is commonly in human pancreatic cancer and provided rationale to explore inhibition of these pathways therapeutically. Notch signaling is important during pancrea...