Why does Japan have a high incidence of gastric cancer? Comparison of gastritis between UK and Japanese patients

• Published in: Gut Vol. 55; no. 11; pp. 1545 - 1552
• Main Authors: Naylor, G M, Gotoda, T, Dixon, M, Shimoda, T, Gatta, L, Owen, R, Tompkins, D, Axon, A
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.11.2006; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Acids; Adult; Age; Aged; Biological and medical sciences; Biopsy; Endoscopy; England - epidemiology; Epidemiologic Methods; Female; Gastric cancer; gastric cancer risk; gastritis; Gastritis - complications; Gastritis - epidemiology; Gastritis - microbiology; Gastritis - pathology; Gastritis, Atrophic - complications; Gastritis, Atrophic - epidemiology; Gastritis, Atrophic - microbiology; Gastritis, Atrophic - pathology; Gastroenterology. Liver. Pancreas. Abdomen; Helicobacter Infections - complications; Helicobacter pylori; Helicobacter pylori - pathogenicity; Histology; Humans; Hypotheses; Infections; Inflammation; interleukin; interquartile range; intestinal metaplasia; IQR; Japan - epidemiology; Male; Medical sciences; Middle Aged; Nitrates; Population; population comparison; Severity of Illness Index; Stomach; Stomach Neoplasms - epidemiology; Stomach Neoplasms - etiology; Stomach Neoplasms - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; TNF-α; Tumors; tumour necrosis factor α; Ulcers; Asia; Japan; England; United Kingdom > UK; Human; Gastroenterology; Digestive diseases; Malignant tumor; Epidemiology; Stomach cancer; Comparative study; Gastric disease; Gastritis; Incidence

Background and aims: The incidence of gastric cancer in Japan is four times higher than in the UK. It usually arises in a stomach with corpus predominant or pangastritis that has undergone extensive atrophy and intestinal metaplasia. We hypothesised that a Japanese population would have a more sever...