Involvement of the skin during bluetongue virus infection and replication in the ruminant host

• Published in: Veterinary research (Paris) Vol. 43; no. 1; pp. 40 - 185
• Main Authors: Darpel, Karin E, Monaghan, Paul, Simpson, Jennifer, Anthony, Simon J, Veronesi, Eva, Brooks, Harriet W, Elliott, Heather, Brownlie, Joe, Takamatsu, Haru-Hisa, Mellor, Philip S, Mertens, Peter PC
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.04.2012; BioMed Central; BMC
• Subjects: Animals; Bluetongue; Bluetongue - virology; Bluetongue virus; Bluetongue virus - genetics; Bluetongue virus - isolation & purification; Bluetongue virus - physiology; Cattle; Ceratopogonidae - physiology; Dendritic cells; Distribution; DNA replication; endothelial cells; Feeding Behavior; Food Chain; Genetic aspects; Health aspects; hosts; Immunohistochemistry - veterinary; Inflammation - veterinary; Inflammation - virology; insects; lymphocytes; Macrophages; microscopy; Microscopy, Confocal - veterinary; monocytes; Organ Specificity; pathogenesis; Proteins; RNA; Sheep; Skin; Skin - virology; structural proteins; tonsils; tropisms; Viral Core Proteins - metabolism; Viral Nonstructural Proteins - metabolism; virus replication; viruses; United Kingdom

Bluetongue virus (BTV) is a double stranded (ds) RNA virus (genus Orbivirus; family Reoviridae), which is considered capable of infecting all species of domestic and wild ruminants, although clinical signs are seen mostly in sheep. BTV is arthropod-borne ("arbovirus") and able to productiv...