Glutathione in gingival crevicular fluid and its relation to local antioxidant capacity in periodontal health and disease

• Published in: Molecular pathology Vol. 55; no. 6; pp. 367 - 373
• Main Authors: Chapple, I L C, Brock, G, Eftimiadi, C, Matthews, J B
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.12.2002; BMJ; BMJ Publishing Group Ltd; British Medical Journal Publishing Group
• Subjects: Adult; alveolar epithelial lining fluid; Antioxidants - analysis; Biological and medical sciences; Chromatography, High Pressure Liquid; Chronic Disease; Cross-Sectional Studies; ECL; ELF; enhanced chemiluminescent; F-Met-Leu-Phe; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; FMLP; GCF; GEC; gingival crevicular fluid; Gingival Crevicular Fluid - chemistry; gingival epithelial cell; Gingivitis; Glutathione; Glutathione - analysis; Glutathione - physiology; GSH; GSSG; Gum diseases; high performance liquid chromatography; HPLC; Humans; Male; Medical sciences; Middle Aged; Neutrophil Activation; NF-κB; Non tumoral diseases; nuclear factor κB; Original; Otorhinolaryngology. Stomatology; Oxidation-Reduction; Oxidation-reduction reaction; oxidised glutathione; Pathology, Molecular; PBS; Periodontitis - metabolism; phosphate buffered saline; Physiological aspects; PMNL; polymorphonuclear leucocyte; reactive oxygen species; reduced glutathione; ROS; Human; Biological fluid; Chronic; Periodontal disease; Biochemical analysis; Stomatology; Pathogenesis; Antiinflammatory agent; Antioxidant; Gingiva; Glutathione

Aims: To determine possible changes in gingival crevicular fluid (GCF) antioxidant defence in chronic adult periodontal disease and to investigate the nature of the local radical scavenging mechanisms, with particular reference to glutathione. Methods: GCF and plasma were collected from patients wit...