Global gene expression analysis reveals reduced abundance of putative microRNA targets in human prostate tumours

• Published in: BMC genomics Vol. 10; no. 1; p. 93
• Main Authors: Sun, Ruping, Fu, Xuping, Li, Yao, Xie, Yi, Mao, Yumin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.02.2009; BioMed Central; BMC
• Subjects: 3' Untranslated Regions - genetics; Androgens - metabolism; DNA microarrays; Down-Regulation; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic aspects; Humans; Male; MicroRNAs - genetics; Oligonucleotide Array Sequence Analysis; Physiological aspects; Prostate cancer; Prostatic Neoplasms - genetics; RNA; RNA, Messenger - genetics; Up-Regulation; China

Recently, microRNAs (miRNAs) have taken centre stage in the field of human molecular oncology. Several studies have shown that miRNA profiling analyses offer new possibilities in cancer classification, diagnosis and prognosis. However, the function of miRNAs that are dysregulated in tumours remains...