Three LIF-dependent signatures and gene clusters with atypical expression profiles, identified by transcriptome studies in mouse ES cells and early derivatives

• Published in: BMC genomics Vol. 10; no. 1; p. 73
• Main Authors: Trouillas, Marina, Saucourt, Claire, Guillotin, Bertrand, Gauthereau, Xavier, Ding, Li, Buchholz, Frank, Doss, Michael Xavier, Sachinidis, Agapios, Hescheler, Jurgen, Hummel, Oliver, Huebner, Norbert, Kolde, Raivo, Vilo, Jaak, Schulz, Herbert, Boeuf, Hélène
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.02.2009; BioMed Central; BMC
• Subjects: Animals; Cell Differentiation - genetics; Cell Line; Cluster Analysis; Cytokines; Embryonic stem cells; Embryonic Stem Cells - metabolism; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genetic aspects; Genetic regulation; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Leukemia Inhibitory Factor - metabolism; Mice - genetics; Nanog Homeobox Protein; Octamer Transcription Factor-3 - genetics; Octamer Transcription Factor-3 - metabolism; Oligonucleotide Array Sequence Analysis; Physiological aspects; Pluripotent Stem Cells - metabolism; France; Germany

Mouse embryonic stem (ES) cells remain pluripotent in vitro when grown in the presence of the cytokine Leukaemia Inhibitory Factor (LIF). Identification of LIF targets and of genes regulating the transition between pluripotent and early differentiated cells is a critical step for understanding the c...