Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel

• Published in: Gut Vol. 53; no. 11; pp. 1610 - 1616
• Main Authors: Langlands, S J, Hopkins, M J, Coleman, N, Cummings, J H
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.11.2004; BMJ; BMJ Publishing Group LTD; Copyright 2004 by Gut
• Subjects: Adult; Aged; Antibiotics; Bacteria; Bacteroides; bifidobacteria; Bifidobacterium - growth & development; biofilm; Biological and medical sciences; Carbohydrates; Cell cycle; Cell Division - drug effects; Colonoscopy; Colony Count, Microbial; Colorectal cancer; Diet; Dietary Supplements - adverse effects; Digestive system. Abdomen; Endoscopy; Eubacteria; Family medical history; Feces - microbiology; Female; Flatulence - etiology; fructose; Gastroenterology. Liver. Pancreas. Abdomen; glucose; Health care; Hospitals; Humans; Immune system; Intestinal Mucosa - cytology; Intestinal Mucosa - microbiology; Intestine, Large - cytology; Intestine, Large - microbiology; Inulin - adverse effects; Inulin - pharmacology; Investigative techniques, diagnostic techniques (general aspects); labelling index; Lactobacillus; large intestine; MAF; Male; Mcm-2; Medical sciences; Metabolism; Middle Aged; minichromosome maintenance protein 2; mucosa associated flora; mucosa associated floral; Nutrition research; Oligosaccharides - adverse effects; Oligosaccharides - pharmacology; PCNA; prebiotic; Prebiotics; Probiotics; proliferating cell nuclear antigen; Rodents; Human; Composition; Eubacteria; Mucosa; Check; Lipids; Method; In vitro; Bacteroidaceae; Bacteroides; Surface; Prevention; Anatomic pathology; Flora; Colonoscopy; Inulin; Bacteria; Carbohydrate; Associated microflora; Models; Endoscopy; Chemostat

Background and aims: The mucosa associated flora of the large intestine is important in determining mucosal function although what controls its composition is unknown. This study has determined the effect of the prebiotic carbohydrates oligofructose and inulin on the mucosal flora. Methods: An in vi...