Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells

• Published in: BMC genomics Vol. 9; no. 1; p. 479
• Main Authors: Wang, Chien-Yu, Staniforth, Vanisree, Chiao, Ming-Tsang, Hou, Chia-Chung, Wu, Han-Ming, Yeh, Kuo-Chen, Chen, Chun-Houh, Hwang, Pei-Ing, Wen, Tuan-Nan, Shyur, Lie-Fen, Yang, Ning-Sun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.10.2008; BioMed Central; BMC
• Subjects: Butanols - chemistry; Caffeic Acids - pharmacology; Chemokines - genetics; Computational Biology; Cytokines - genetics; Cytoskeletal Proteins - metabolism; Dendritic cells; Dendritic Cells - drug effects; Dendritic Cells - immunology; Dendritic Cells - metabolism; Echinacea; Echinacea - chemistry; Gene Expression - drug effects; Gene Expression Profiling; Genetic aspects; Genomics - methods; Health aspects; Humans; Materia medica, Vegetable; Molecular Structure; Oligonucleotide Array Sequence Analysis; Plant extracts; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Leaves - chemistry; Plant Stems - chemistry; Proteomics - methods; Succinates - pharmacology; Taiwan

Echinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as food supplements or nutraceuticals for immuno-modulatory functions. Dendritic cells (DCs), the most potent antigen presenting cells, play an important role in bo...