Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells
Echinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as food supplements or nutraceuticals for immuno-modulatory functions. Dendritic cells (DCs), the most potent antigen presenting cells, play an important role in bo...
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Published in | BMC genomics Vol. 9; no. 1; p. 479 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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13.10.2008
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Abstract | Echinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as food supplements or nutraceuticals for immuno-modulatory functions. Dendritic cells (DCs), the most potent antigen presenting cells, play an important role in both innate and adaptive immunities. In this study, we investigated the specific and differential gene expression in human immature DCs (iDCs) in response to treatment with a butanol fraction containing defined bioactive phytocompounds extracted from stems and leaves of Echinacea purpurea, that we denoted [BF/S+L/Ep].
Affymetrix DNA microarray results showed significant up regulation of specific genes for cytokines (IL-8, IL-1beta, and IL-18) and chemokines (CXCL 2, CCL 5, and CCL 2) within 4 h after [BF/S+L/Ep] treatment of iDCs. Bioinformatics analysis of genes expressed in [BF/S+L/Ep]-treated DCs revealed a key-signaling network involving a number of immune-modulatory molecules leading to the activation of a downstream molecule, adenylate cyclase 8. Proteomic analysis showed increased expression of antioxidant and cytoskeletal proteins after treatment with [BF/S+L/Ep] and cichoric acid.
This study provides information on candidate target molecules and molecular signaling mechanisms for future systematic research into the immune-modulatory activities of an important traditional medicinal herb and its derived phytocompounds. |
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AbstractList | Echinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as food supplements or nutraceuticals for immuno-modulatory functions. Dendritic cells (DCs), the most potent antigen presenting cells, play an important role in both innate and adaptive immunities. In this study, we investigated the specific and differential gene expression in human immature DCs (iDCs) in response to treatment with a butanol fraction containing defined bioactive phytocompounds extracted from stems and leaves of Echinacea purpurea, that we denoted [BF/S+L/Ep].
Affymetrix DNA microarray results showed significant up regulation of specific genes for cytokines (IL-8, IL-1beta, and IL-18) and chemokines (CXCL 2, CCL 5, and CCL 2) within 4 h after [BF/S+L/Ep] treatment of iDCs. Bioinformatics analysis of genes expressed in [BF/S+L/Ep]-treated DCs revealed a key-signaling network involving a number of immune-modulatory molecules leading to the activation of a downstream molecule, adenylate cyclase 8. Proteomic analysis showed increased expression of antioxidant and cytoskeletal proteins after treatment with [BF/S+L/Ep] and cichoric acid.
This study provides information on candidate target molecules and molecular signaling mechanisms for future systematic research into the immune-modulatory activities of an important traditional medicinal herb and its derived phytocompounds. Abstract Background Echinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as food supplements or nutraceuticals for immuno-modulatory functions. Dendritic cells (DCs), the most potent antigen presenting cells, play an important role in both innate and adaptive immunities. In this study, we investigated the specific and differential gene expression in human immature DCs (iDCs) in response to treatment with a butanol fraction containing defined bioactive phytocompounds extracted from stems and leaves of Echinacea purpurea, that we denoted [BF/S+L/Ep]. Results Affymetrix DNA microarray results showed significant up regulation of specific genes for cytokines (IL-8, IL-1β, and IL-18) and chemokines (CXCL 2, CCL 5, and CCL 2) within 4 h after [BF/S+L/Ep] treatment of iDCs. Bioinformatics analysis of genes expressed in [BF/S+L/Ep]-treated DCs revealed a key-signaling network involving a number of immune-modulatory molecules leading to the activation of a downstream molecule, adenylate cyclase 8. Proteomic analysis showed increased expression of antioxidant and cytoskeletal proteins after treatment with [BF/S+L/Ep] and cichoric acid. Conclusion This study provides information on candidate target molecules and molecular signaling mechanisms for future systematic research into the immune-modulatory activities of an important traditional medicinal herb and its derived phytocompounds. BACKGROUND: Echinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as food supplements or nutraceuticals for immuno-modulatory functions. Dendritic cells (DCs), the most potent antigen presenting cells, play an important role in both innate and adaptive immunities. In this study, we investigated the specific and differential gene expression in human immature DCs (iDCs) in response to treatment with a butanol fraction containing defined bioactive phytocompounds extracted from stems and leaves of Echinacea purpurea, that we denoted [BF/S+L/Ep]. RESULTS: Affymetrix DNA microarray results showed significant up regulation of specific genes for cytokines (IL-8, IL-1β, and IL-18) and chemokines (CXCL 2, CCL 5, and CCL 2) within 4 h after [BF/S+L/Ep] treatment of iDCs. Bioinformatics analysis of genes expressed in [BF/S+L/Ep]-treated DCs revealed a key-signaling network involving a number of immune-modulatory molecules leading to the activation of a downstream molecule, adenylate cyclase 8. Proteomic analysis showed increased expression of antioxidant and cytoskeletal proteins after treatment with [BF/S+L/Ep] and cichoric acid. CONCLUSION: This study provides information on candidate target molecules and molecular signaling mechanisms for future systematic research into the immune-modulatory activities of an important traditional medicinal herb and its derived phytocompounds. Abstract Background Echinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as food supplements or nutraceuticals for immuno-modulatory functions. Dendritic cells (DCs), the most potent antigen presenting cells, play an important role in both innate and adaptive immunities. In this study, we investigated the specific and differential gene expression in human immature DCs (iDCs) in response to treatment with a butanol fraction containing defined bioactive phytocompounds extracted from stems and leaves of Echinacea purpurea , that we denoted [BF/S+L/Ep]. Results Affymetrix DNA microarray results showed significant up regulation of specific genes for cytokines (IL-8, IL-1β, and IL-18) and chemokines (CXCL 2, CCL 5, and CCL 2) within 4 h after [BF/S+L/Ep] treatment of iDCs. Bioinformatics analysis of genes expressed in [BF/S+L/Ep]-treated DCs revealed a key-signaling network involving a number of immune-modulatory molecules leading to the activation of a downstream molecule, adenylate cyclase 8. Proteomic analysis showed increased expression of antioxidant and cytoskeletal proteins after treatment with [BF/S+L/Ep] and cichoric acid. Conclusion This study provides information on candidate target molecules and molecular signaling mechanisms for future systematic research into the immune-modulatory activities of an important traditional medicinal herb and its derived phytocompounds. BACKGROUNDEchinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as food supplements or nutraceuticals for immuno-modulatory functions. Dendritic cells (DCs), the most potent antigen presenting cells, play an important role in both innate and adaptive immunities. In this study, we investigated the specific and differential gene expression in human immature DCs (iDCs) in response to treatment with a butanol fraction containing defined bioactive phytocompounds extracted from stems and leaves of Echinacea purpurea, that we denoted [BF/S+L/Ep].RESULTSAffymetrix DNA microarray results showed significant up regulation of specific genes for cytokines (IL-8, IL-1beta, and IL-18) and chemokines (CXCL 2, CCL 5, and CCL 2) within 4 h after [BF/S+L/Ep] treatment of iDCs. Bioinformatics analysis of genes expressed in [BF/S+L/Ep]-treated DCs revealed a key-signaling network involving a number of immune-modulatory molecules leading to the activation of a downstream molecule, adenylate cyclase 8. Proteomic analysis showed increased expression of antioxidant and cytoskeletal proteins after treatment with [BF/S+L/Ep] and cichoric acid.CONCLUSIONThis study provides information on candidate target molecules and molecular signaling mechanisms for future systematic research into the immune-modulatory activities of an important traditional medicinal herb and its derived phytocompounds. |
ArticleNumber | 479 |
Audience | Academic |
Author | Chiao, Ming-Tsang Hwang, Pei-Ing Hou, Chia-Chung Wang, Chien-Yu Wen, Tuan-Nan Staniforth, Vanisree Wu, Han-Ming Yeh, Kuo-Chen Shyur, Lie-Fen Chen, Chun-Houh Yang, Ning-Sun |
AuthorAffiliation | 3 Institute of Statistical Science, Academia Sinica, Taipei 115, Taiwan 1 Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan 2 Institute of Plant and Microbial Biology, Academia Sinica, Taipei 115, Taiwan |
AuthorAffiliation_xml | – name: 2 Institute of Plant and Microbial Biology, Academia Sinica, Taipei 115, Taiwan – name: 1 Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan – name: 3 Institute of Statistical Science, Academia Sinica, Taipei 115, Taiwan |
Author_xml | – sequence: 1 givenname: Chien-Yu surname: Wang fullname: Wang, Chien-Yu email: sally@mail.biowell.com.tw organization: Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan. sally@mail.biowell.com.tw – sequence: 2 givenname: Vanisree surname: Staniforth fullname: Staniforth, Vanisree – sequence: 3 givenname: Ming-Tsang surname: Chiao fullname: Chiao, Ming-Tsang – sequence: 4 givenname: Chia-Chung surname: Hou fullname: Hou, Chia-Chung – sequence: 5 givenname: Han-Ming surname: Wu fullname: Wu, Han-Ming – sequence: 6 givenname: Kuo-Chen surname: Yeh fullname: Yeh, Kuo-Chen – sequence: 7 givenname: Chun-Houh surname: Chen fullname: Chen, Chun-Houh – sequence: 8 givenname: Pei-Ing surname: Hwang fullname: Hwang, Pei-Ing – sequence: 9 givenname: Tuan-Nan surname: Wen fullname: Wen, Tuan-Nan – sequence: 10 givenname: Lie-Fen surname: Shyur fullname: Shyur, Lie-Fen – sequence: 11 givenname: Ning-Sun surname: Yang fullname: Yang, Ning-Sun |
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Snippet | Echinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as food supplements or... Abstract Background Echinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as... BACKGROUNDEchinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as food... BACKGROUND: Echinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as food... Abstract Background Echinacea spp. extracts and the derived phytocompounds have been shown to induce specific immune cell activities and are popularly used as... |
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SubjectTerms | Butanols - chemistry Caffeic Acids - pharmacology Chemokines - genetics Computational Biology Cytokines - genetics Cytoskeletal Proteins - metabolism Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Echinacea Echinacea - chemistry Gene Expression - drug effects Gene Expression Profiling Genetic aspects Genomics - methods Health aspects Humans Materia medica, Vegetable Molecular Structure Oligonucleotide Array Sequence Analysis Plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Plant Stems - chemistry Proteomics - methods Succinates - pharmacology |
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Title | Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells |
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