Rhythmic Cilium in SCN Neuron is a Gatekeeper for the Intrinsic Circadian Clock

• Published in: bioRxiv
• Main Authors: Hai-Qing, Tu, Sen, Li, Yu-Ling, Xu, Yu-Cheng, Zhang, Xiao-Xiao, Jian, Song Guang-Ping, Wu, Min, Zeng-Qing, Song, Hu Huai-Bin, Pei-Yao, Li, Li-Yun, Liang, Jin-Feng, Yuan, Xiao-Lin, Shen, Jia-Ning, Li, Qiu-Ying, Han, Wang, Kai, Zhang, Tao, Zhou, Tao, Ai-Ling, Li, Xue-Min, Zhang, Hui-Yan, Li
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 31.01.2022; Cold Spring Harbor Laboratory
• Edition: 1.2
• Subjects: Ablation; Brain slice preparation; Cilia; Circadian rhythm; Circadian rhythms; Hedgehog protein; Hypothalamus; Neuromedin; Neurons; Neuroscience; Oscillations; Pacemakers; Suprachiasmatic nucleus

The internal circadian rhythm is controlled by the central pacemaker in the hypothalamic suprachiasmatic nucleus (SCN). SCN drives coherent and synchronized circadian oscillations via intercellular coupling, which are resistant to environmental perturbations. Here we report that primary cilium is a...