Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease

• Published in: Current Alzheimer research Vol. 14; no. 4; p. 412
• Main Authors: Decourt, Boris, Lahiri, Debomoy K, Sabbagh, Marwan N
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2017
• Subjects: Alzheimer Disease - drug therapy; Alzheimer Disease - genetics; Alzheimer Disease - immunology; Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Humans; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; BACE1; thalidomide; TNF-alpha; inflammation; neuroinflammation; etanercept; Alzheimer's disease

Alzheimer's disease (AD) affects an estimated 44 million individuals worldwide, yet no therapeutic intervention is available to stop the progression of the dementia. Neuropathological hallmarks of AD are extracellular deposits of amyloid beta (Aβ) peptides assembled in plaques, intraneuronal ac...