Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma

• Published in: Respiratory research Vol. 14; no. 1; p. 17
• Main Authors: Desai, Dhananjay, Gupta, Sumit, Siddiqui, Salman, Singapuri, Amisha, Monteiro, William, Entwisle, James, Visvanathan, Sudha, Parmar, Harsukh, Kajekar, Radhika, Brightling, Christopher E
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.02.2013; BioMed Central; BMC
• Subjects: Adult; Airway (Medicine); Airway Remodeling; Analysis; Asthma; Asthma - diagnosis; Asthma - diagnostic imaging; Asthma - immunology; Biomarkers - analysis; Biomedical research; Chemokine CCL11 - analysis; Chronic obstructive pulmonary disease; Cross-Sectional Studies; Development and progression; Drug dosages; England; Female; Fibrin; Fibrinogen; Fibrinogen - analysis; Geometry; Humans; Inflammation; Inflammation Mediators - analysis; Intercellular Adhesion Molecule-1 - analysis; Interleukin-1alpha - analysis; Interleukin-1beta - analysis; Leukocyte Count; Lung - diagnostic imaging; Lung - immunology; Male; Matrix Metalloproteinase 9 - analysis; Measurement; Mediators; Medical imaging; Middle Aged; Mortality; Neutrophils - immunology; Phenotype; Physiological aspects; Predictive Value of Tests; RB1 bronchus; Remodelling; Retrospective Studies; Severity of Illness Index; Sputum; Sputum - immunology; Tomography; Tomography, X-Ray Computed; United Kingdom

Severe asthma is a heterogeneous disease and the relationship between airway inflammation and airway remodelling is poorly understood. We sought to define sputum mediator profiles in severe asthmatics categorised by CT-determined airway geometry and sputum differential cell counts. In a single centr...