Tenascin-W is a better cancer biomarker than tenascin-C for most human solid tumors

• Published in: BMC clinical pathology Vol. 12; no. 1; p. 14
• Main Authors: Brellier, Florence, Martina, Enrico, Degen, Martin, Heuzé-Vourc'h, Nathalie, Petit, Agnès, Kryza, Thomas, Courty, Yves, Terracciano, Luigi, Ruiz, Christian, Chiquet-Ehrismann, Ruth
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.09.2012; BioMed Central
• Subjects: Analysis; Biological markers; Biomarkers; Biomedical research; Brain; Brain cancer; Cancer; Cancer therapies; Diagnosis; Gliomas; Glycoproteins; Hospitals; Immunohistochemistry; Lung cancer; Medical equipment and supplies industry; Medical test kit industry; Melanoma; Metastasis; Pathology; Physiological aspects; Proteins; Tumors; France; United States; Switzerland

Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its high overexpression in the stroma of most solid cancers. Tenascin-W, the least studied member of the family, is highly expressed in the stroma...