Tenascin-W is a better cancer biomarker than tenascin-C for most human solid tumors

Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its high overexpression in the stroma of most solid cancers. Tenascin-W, the least studied member of the family, is highly expressed in the stroma...

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Published inBMC clinical pathology Vol. 12; no. 1; p. 14
Main Authors Brellier, Florence, Martina, Enrico, Degen, Martin, Heuzé-Vourc'h, Nathalie, Petit, Agnès, Kryza, Thomas, Courty, Yves, Terracciano, Luigi, Ruiz, Christian, Chiquet-Ehrismann, Ruth
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 04.09.2012
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Abstract Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its high overexpression in the stroma of most solid cancers. Tenascin-W, the least studied member of the family, is highly expressed in the stroma of colon and breast tumors and in gliomas, but not in the corresponding normal tissues. Other solid tumors have not been analyzed. The present study was undertaken to determine whether tenascin-W could serve as a cancer-specific extracellular matrix protein in a broad range of solid tumors. We analyzed the expression of tenascin-W and tenascin-C by immunoblotting and by immunohistochemistry on multiple frozen tissue microarrays of carcinomas of the pancreas, kidney and lung as well as melanomas and compared them to healthy tissues. From all healthy adult organs tested, only liver and spleen showed detectable levels of tenascin-W, suggesting that tenascin-W is absent from most human adult organs under normal, non-pathological conditions. In contrast, tenascin-W was detectable in the majority of melanomas and their metastases, as well as in pancreas, kidney, and lung carcinomas. Comparing lung tumor samples and matching control tissues for each patient revealed a clear overexpression of tenascin-W in tumor tissues. Although the number of samples examined is too small to draw statistically significant conclusions, there seems to be a tendency for increased tenascin-W expression in higher grade tumors. Interestingly, in most tumor types, tenascin-W is also expressed in close proximity to blood vessels, as shown by CD31 co-staining of the samples. The present study extends the tumor biomarker potential of tenascin-W to a broad range of solid tumors and shows its accessibility from the blood stream for potential therapeutic strategies.
AbstractList Background Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its high overexpression in the stroma of most solid cancers. Tenascin-W, the least studied member of the family, is highly expressed in the stroma of colon and breast tumors and in gliomas, but not in the corresponding normal tissues. Other solid tumors have not been analyzed. The present study was undertaken to determine whether tenascin-W could serve as a cancer-specific extracellular matrix protein in a broad range of solid tumors. Methods We analyzed the expression of tenascin-W and tenascin-C by immunoblotting and by immunohistochemistry on multiple frozen tissue microarrays of carcinomas of the pancreas, kidney and lung as well as melanomas and compared them to healthy tissues. Results From all healthy adult organs tested, only liver and spleen showed detectable levels of tenascin-W, suggesting that tenascin-W is absent from most human adult organs under normal, non-pathological conditions. In contrast, tenascin-W was detectable in the majority of melanomas and their metastases, as well as in pancreas, kidney, and lung carcinomas. Comparing lung tumor samples and matching control tissues for each patient revealed a clear overexpression of tenascin-W in tumor tissues. Although the number of samples examined is too small to draw statistically significant conclusions, there seems to be a tendency for increased tenascin-W expression in higher grade tumors. Interestingly, in most tumor types, tenascin-W is also expressed in close proximity to blood vessels, as shown by CD31 co-staining of the samples. Conclusions The present study extends the tumor biomarker potential of tenascin-W to a broad range of solid tumors and shows its accessibility from the blood stream for potential therapeutic strategies.
BACKGROUNDTenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its high overexpression in the stroma of most solid cancers. Tenascin-W, the least studied member of the family, is highly expressed in the stroma of colon and breast tumors and in gliomas, but not in the corresponding normal tissues. Other solid tumors have not been analyzed. The present study was undertaken to determine whether tenascin-W could serve as a cancer-specific extracellular matrix protein in a broad range of solid tumors. METHODSWe analyzed the expression of tenascin-W and tenascin-C by immunoblotting and by immunohistochemistry on multiple frozen tissue microarrays of carcinomas of the pancreas, kidney and lung as well as melanomas and compared them to healthy tissues. RESULTSFrom all healthy adult organs tested, only liver and spleen showed detectable levels of tenascin-W, suggesting that tenascin-W is absent from most human adult organs under normal, non-pathological conditions. In contrast, tenascin-W was detectable in the majority of melanomas and their metastases, as well as in pancreas, kidney, and lung carcinomas. Comparing lung tumor samples and matching control tissues for each patient revealed a clear overexpression of tenascin-W in tumor tissues. Although the number of samples examined is too small to draw statistically significant conclusions, there seems to be a tendency for increased tenascin-W expression in higher grade tumors. Interestingly, in most tumor types, tenascin-W is also expressed in close proximity to blood vessels, as shown by CD31 co-staining of the samples. CONCLUSIONSThe present study extends the tumor biomarker potential of tenascin-W to a broad range of solid tumors and shows its accessibility from the blood stream for potential therapeutic strategies.
Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its high overexpression in the stroma of most solid cancers. Tenascin-W, the least studied member of the family, is highly expressed in the stroma of colon and breast tumors and in gliomas, but not in the corresponding normal tissues. Other solid tumors have not been analyzed. The present study was undertaken to determine whether tenascin-W could serve as a cancer-specific extracellular matrix protein in a broad range of solid tumors. We analyzed the expression of tenascin-W and tenascin-C by immunoblotting and by immunohistochemistry on multiple frozen tissue microarrays of carcinomas of the pancreas, kidney and lung as well as melanomas and compared them to healthy tissues. From all healthy adult organs tested, only liver and spleen showed detectable levels of tenascin-W, suggesting that tenascin-W is absent from most human adult organs under normal, non-pathological conditions. In contrast, tenascin-W was detectable in the majority of melanomas and their metastases, as well as in pancreas, kidney, and lung carcinomas. Comparing lung tumor samples and matching control tissues for each patient revealed a clear overexpression of tenascin-W in tumor tissues. Although the number of samples examined is too small to draw statistically significant conclusions, there seems to be a tendency for increased tenascin-W expression in higher grade tumors. Interestingly, in most tumor types, tenascin-W is also expressed in close proximity to blood vessels, as shown by CD31 co-staining of the samples. The present study extends the tumor biomarker potential of tenascin-W to a broad range of solid tumors and shows its accessibility from the blood stream for potential therapeutic strategies.
Doc number: 14 Abstract Background: Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its high overexpression in the stroma of most solid cancers. Tenascin-W, the least studied member of the family, is highly expressed in the stroma of colon and breast tumors and in gliomas, but not in the corresponding normal tissues. Other solid tumors have not been analyzed. The present study was undertaken to determine whether tenascin-W could serve as a cancer-specific extracellular matrix protein in a broad range of solid tumors. Methods: We analyzed the expression of tenascin-W and tenascin-C by immunoblotting and by immunohistochemistry on multiple frozen tissue microarrays of carcinomas of the pancreas, kidney and lung as well as melanomas and compared them to healthy tissues. Results: From all healthy adult organs tested, only liver and spleen showed detectable levels of tenascin-W, suggesting that tenascin-W is absent from most human adult organs under normal, non-pathological conditions. In contrast, tenascin-W was detectable in the majority of melanomas and their metastases, as well as in pancreas, kidney, and lung carcinomas. Comparing lung tumor samples and matching control tissues for each patient revealed a clear overexpression of tenascin-W in tumor tissues. Although the number of samples examined is too small to draw statistically significant conclusions, there seems to be a tendency for increased tenascin-W expression in higher grade tumors. Interestingly, in most tumor types, tenascin-W is also expressed in close proximity to blood vessels, as shown by CD31 co-staining of the samples. Conclusions: The present study extends the tumor biomarker potential of tenascin-W to a broad range of solid tumors and shows its accessibility from the blood stream for potential therapeutic strategies.
Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its high overexpression in the stroma of most solid cancers. Tenascin-W, the least studied member of the family, is highly expressed in the stroma of colon and breast tumors and in gliomas, but not in the corresponding normal tissues. Other solid tumors have not been analyzed. The present study was undertaken to determine whether tenascin-W could serve as a cancer-specific extracellular matrix protein in a broad range of solid tumors. We analyzed the expression of tenascin-W and tenascin-C by immunoblotting and by immunohistochemistry on multiple frozen tissue microarrays of carcinomas of the pancreas, kidney and lung as well as melanomas and compared them to healthy tissues. From all healthy adult organs tested, only liver and spleen showed detectable levels of tenascin-W, suggesting that tenascin-W is absent from most human adult organs under normal, non-pathological conditions. In contrast, tenascin-W was detectable in the majority of melanomas and their metastases, as well as in pancreas, kidney, and lung carcinomas. Comparing lung tumor samples and matching control tissues for each patient revealed a clear overexpression of tenascin-W in tumor tissues. Although the number of samples examined is too small to draw statistically significant conclusions, there seems to be a tendency for increased tenascin-W expression in higher grade tumors. Interestingly, in most tumor types, tenascin-W is also expressed in close proximity to blood vessels, as shown by CD31 co-staining of the samples. The present study extends the tumor biomarker potential of tenascin-W to a broad range of solid tumors and shows its accessibility from the blood stream for potential therapeutic strategies.
ArticleNumber 14
Audience Academic
Author Martina, Enrico
Brellier, Florence
Courty, Yves
Petit, Agnès
Kryza, Thomas
Terracciano, Luigi
Chiquet-Ehrismann, Ruth
Ruiz, Christian
Degen, Martin
Heuzé-Vourc'h, Nathalie
AuthorAffiliation 2 Faculty of Sciences, University of Basel, Basel, Switzerland
3 Université François Rabelais, EA 6305, F-37032, Tours, France
1 Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
4 Centre d'Etude des Pathologies Respiratoires, UMR 1100/EA6305, F-37032, Tours, France
5 Institute of Pathology, University Hospital Basel, Basel, Switzerland
6 Present address: Department of Dermatology, Brigham and Women’s Hospital, Harvard Skin Disease Research Center, Harvard Medical School, Boston, MA, USA
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Cites_doi 10.1038/nature10525
10.1007/s12079-009-0075-1
10.1007/s00418-011-0886-z
10.1038/onc.2010.350
10.1007/s00018-011-0783-6
10.1016/j.leukres.2009.06.025
10.1002/path.1415
10.1158/1078-0432.CCR-11-1203
10.1073/pnas.84.13.4621
10.4161/cc.9.15.12710
10.1002/ijc.23417
10.1096/fj.09-140491
10.1038/nm.2328
10.1016/j.biocel.2010.06.004
10.1158/1078-0432.CCR-11-0483
10.7150/ijbs.8.187
10.1016/j.cell.2011.02.013
10.1586/14737140.7.5.675
10.1158/1078-0432.CCR-05-2804
10.1101/cshperspect.a004960
10.1111/j.1365-2133.1995.tb02486.x
10.1016/j.ccr.2006.11.020
10.1111/j.1582-4934.2011.01360.x
10.1016/j.cell.2011.11.016
10.1016/j.biomaterials.2010.10.034
10.1007/s00418-010-0685-y
10.1158/0008-5472.CAN-07-0666
10.1016/j.ejca.2010.07.033
10.1016/j.canlet.2006.02.017
10.1038/nn.2955
10.1242/jcs.00867
10.1038/nature03100
10.1007/s10555-010-9249-9
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References 15549094 - Nature. 2004 Nov 18;432(7015):324-31
20541035 - Int J Biochem Cell Biol. 2010 Sep;42(9):1412-5
22012397 - Nature. 2011 Oct 20;478(7369):399-403
19838819 - J Cell Commun Signal. 2009 Dec;3(3-4):287-310
21071077 - Biomaterials. 2011 Feb;32(4):1130-8
22118458 - Cell. 2011 Nov 23;147(5):992-1009
7530138 - Perspect Dev Neurobiol. 1994;2(1):117-23
20814719 - Cancer Metastasis Rev. 2010 Dec;29(4):595-606
20237793 - Histochem Cell Biol. 2010 Apr;133(4):467-75
14709716 - J Cell Sci. 2004 Feb 1;117(Pt 4):571-81
21692981 - J Cell Mol Med. 2012 Jan;16(1):32-40
21383745 - Nat Med. 2011 Mar;17(3):320-9
20714216 - Cell Cycle. 2010 Aug 1;9(15):3012-21
21376230 - Cell. 2011 Mar 4;144(5):646-74
16707621 - Clin Cancer Res. 2006 May 15;12(10):3200-8
19625084 - Leuk Res. 2009 Dec;33(12):1718-22
20729912 - Oncogene. 2010 Nov 18;29(46):6115-24
16595502 - J Nucl Med. 2006 Apr;47(4):668-78
17492931 - Expert Rev Anticancer Ther. 2007 May;7(5):675-87
22030548 - Nat Neurosci. 2011 Nov;14(11):1375-81
22003068 - Clin Cancer Res. 2011 Oct 15;17(20):6406-16
18306355 - Int J Cancer. 2008 Jun 1;122(11):2454-61
2440026 - Proc Natl Acad Sci U S A. 1987 Jul;84(13):4621-5
17909022 - Cancer Res. 2007 Oct 1;67(19):9169-79
20797845 - Eur J Cancer. 2010 Nov;46(16):2926-35
21818551 - Cell Mol Life Sci. 2011 Oct;68(19):3175-99
22211116 - Int J Biol Sci. 2012;8(2):187-94
12845616 - J Pathol. 2003 Jul;200(4):488-99
17222791 - Cancer Cell. 2007 Jan;11(1):69-82
21441591 - Cold Spring Harb Perspect Biol. 2011 May;3(5). pii: a004960. doi: 10.1101/cshperspect.a004960
19884327 - FASEB J. 2010 Mar;24(3):778-87
7545419 - Br J Dermatol. 1995 Jul;133(1):13-22
22075565 - Histochem Cell Biol. 2012 Feb;137(2):195-204
16632194 - Cancer Lett. 2006 Dec 8;244(2):143-63
22028492 - Clin Cancer Res. 2011 Dec 15;17(24):7732-42
BJ Hicke (101_CR16) 2006; 47
M Fukunaga-Kalabis (101_CR31) 2010; 29
KS Midwood (101_CR11) 2011; 68
S Schliemann (101_CR12) 2009; 33
AB Hjelmeland (101_CR32) 2011; 14
E Martina (101_CR19) 2010; 24
SS Brack (101_CR25) 2006; 12
PA Beachy (101_CR30) 2004; 432
m Bissell (101_CR4) 2011; 17
G Orend (101_CR10) 2006; 244
K Galler (101_CR23) 2012; 137
DA Reardon (101_CR14) 2007; 7
A Scherberich (101_CR22) 2004; 117
D Hanahan (101_CR3) 2011; 144
C Calabrese (101_CR34) 2007; 11
M Steiner (101_CR13) 2011; 17
P Friedl (101_CR1) 2011; 147
A Leprini (101_CR20) 1994; 2
EJ Mackie (101_CR9) 1987; 84
S Schenk (101_CR21) 1995; 133
KS Midwood (101_CR8) 2009; 3
TK Eigentler (101_CR26) 2011; 17
HY Ko (101_CR15) 2011; 32
DS Guttery (101_CR24) 2010; 29
B Beck (101_CR33) 2011; 478
M Degen (101_CR18) 2008; 122
e Martina (101_CR6) 2010; 42
M Degen (101_CR17) 2007; 67
F Brellier (101_CR2) 2012; 16
R Chiquet-Ehrismann (101_CR5) 2011; 3
F Brellier (101_CR28) 2012; 8
N Charles (101_CR35) 2010; 9
A Berndt (101_CR29) 2010; 133
R Chiquet-Ehrismann (101_CR7) 2003; 200
M Johannsen (101_CR27) 2010; 46
References_xml – volume: 478
  start-page: 399
  year: 2011
  ident: 101_CR33
  publication-title: Nature
  doi: 10.1038/nature10525
  contributor:
    fullname: B Beck
– volume: 3
  start-page: 287
  year: 2009
  ident: 101_CR8
  publication-title: J Cell Commun Signal
  doi: 10.1007/s12079-009-0075-1
  contributor:
    fullname: KS Midwood
– volume: 137
  start-page: 195
  year: 2012
  ident: 101_CR23
  publication-title: Histochem Cell Biol
  doi: 10.1007/s00418-011-0886-z
  contributor:
    fullname: K Galler
– volume: 29
  start-page: 6115
  year: 2010
  ident: 101_CR31
  publication-title: Oncogene
  doi: 10.1038/onc.2010.350
  contributor:
    fullname: M Fukunaga-Kalabis
– volume: 68
  start-page: 3175
  year: 2011
  ident: 101_CR11
  publication-title: CMLS
  doi: 10.1007/s00018-011-0783-6
  contributor:
    fullname: KS Midwood
– volume: 33
  start-page: 1718
  year: 2009
  ident: 101_CR12
  publication-title: Leuk Res
  doi: 10.1016/j.leukres.2009.06.025
  contributor:
    fullname: S Schliemann
– volume: 200
  start-page: 488
  year: 2003
  ident: 101_CR7
  publication-title: J Pathol
  doi: 10.1002/path.1415
  contributor:
    fullname: R Chiquet-Ehrismann
– volume: 17
  start-page: 7732
  year: 2011
  ident: 101_CR26
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-11-1203
  contributor:
    fullname: TK Eigentler
– volume: 2
  start-page: 117
  year: 1994
  ident: 101_CR20
  publication-title: Perspect Dev Neurobiol
  contributor:
    fullname: A Leprini
– volume: 84
  start-page: 4621
  year: 1987
  ident: 101_CR9
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.84.13.4621
  contributor:
    fullname: EJ Mackie
– volume: 9
  start-page: 3012
  year: 2010
  ident: 101_CR35
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.15.12710
  contributor:
    fullname: N Charles
– volume: 122
  start-page: 2454
  year: 2008
  ident: 101_CR18
  publication-title: Int J Cancer
  doi: 10.1002/ijc.23417
  contributor:
    fullname: M Degen
– volume: 24
  start-page: 778
  year: 2010
  ident: 101_CR19
  publication-title: FASEB J
  doi: 10.1096/fj.09-140491
  contributor:
    fullname: E Martina
– volume: 17
  start-page: 320
  year: 2011
  ident: 101_CR4
  publication-title: Nat Med
  doi: 10.1038/nm.2328
  contributor:
    fullname: m Bissell
– volume: 42
  start-page: 1412
  year: 2010
  ident: 101_CR6
  publication-title: Int J Biochem Cell Biol
  doi: 10.1016/j.biocel.2010.06.004
  contributor:
    fullname: e Martina
– volume: 17
  start-page: 6406
  year: 2011
  ident: 101_CR13
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-11-0483
  contributor:
    fullname: M Steiner
– volume: 8
  start-page: 187
  year: 2012
  ident: 101_CR28
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.8.187
  contributor:
    fullname: F Brellier
– volume: 144
  start-page: 646
  year: 2011
  ident: 101_CR3
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
  contributor:
    fullname: D Hanahan
– volume: 7
  start-page: 675
  year: 2007
  ident: 101_CR14
  publication-title: Expert Rev Anticancer Ther
  doi: 10.1586/14737140.7.5.675
  contributor:
    fullname: DA Reardon
– volume: 12
  start-page: 3200
  year: 2006
  ident: 101_CR25
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-05-2804
  contributor:
    fullname: SS Brack
– volume: 3
  start-page: a004960
  year: 2011
  ident: 101_CR5
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a004960
  contributor:
    fullname: R Chiquet-Ehrismann
– volume: 133
  start-page: 13
  year: 1995
  ident: 101_CR21
  publication-title: Br J Dermatol
  doi: 10.1111/j.1365-2133.1995.tb02486.x
  contributor:
    fullname: S Schenk
– volume: 11
  start-page: 69
  year: 2007
  ident: 101_CR34
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2006.11.020
  contributor:
    fullname: C Calabrese
– volume: 16
  start-page: 32
  year: 2012
  ident: 101_CR2
  publication-title: J Cell Mol Med
  doi: 10.1111/j.1582-4934.2011.01360.x
  contributor:
    fullname: F Brellier
– volume: 147
  start-page: 992
  year: 2011
  ident: 101_CR1
  publication-title: Cell
  doi: 10.1016/j.cell.2011.11.016
  contributor:
    fullname: P Friedl
– volume: 32
  start-page: 1130
  year: 2011
  ident: 101_CR15
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2010.10.034
  contributor:
    fullname: HY Ko
– volume: 133
  start-page: 467
  year: 2010
  ident: 101_CR29
  publication-title: Histochem Cell Biol
  doi: 10.1007/s00418-010-0685-y
  contributor:
    fullname: A Berndt
– volume: 67
  start-page: 9169
  year: 2007
  ident: 101_CR17
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-07-0666
  contributor:
    fullname: M Degen
– volume: 46
  start-page: 2926
  year: 2010
  ident: 101_CR27
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2010.07.033
  contributor:
    fullname: M Johannsen
– volume: 244
  start-page: 143
  year: 2006
  ident: 101_CR10
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2006.02.017
  contributor:
    fullname: G Orend
– volume: 14
  start-page: 1375
  year: 2011
  ident: 101_CR32
  publication-title: Nat Neurosci
  doi: 10.1038/nn.2955
  contributor:
    fullname: AB Hjelmeland
– volume: 47
  start-page: 668
  year: 2006
  ident: 101_CR16
  publication-title: J Nuclear Med
  contributor:
    fullname: BJ Hicke
– volume: 117
  start-page: 571
  year: 2004
  ident: 101_CR22
  publication-title: J Cell Sci
  doi: 10.1242/jcs.00867
  contributor:
    fullname: A Scherberich
– volume: 432
  start-page: 324
  year: 2004
  ident: 101_CR30
  publication-title: Nature
  doi: 10.1038/nature03100
  contributor:
    fullname: PA Beachy
– volume: 29
  start-page: 595
  year: 2010
  ident: 101_CR24
  publication-title: Cancer Metastasis Rev
  doi: 10.1007/s10555-010-9249-9
  contributor:
    fullname: DS Guttery
SSID ssj0017812
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Snippet Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its...
Background Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker...
Doc number: 14 Abstract Background: Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a...
BACKGROUNDTenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known...
BACKGROUND: Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker...
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SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 14
SubjectTerms Analysis
Biological markers
Biomarkers
Biomedical research
Brain
Brain cancer
Cancer
Cancer therapies
Diagnosis
Gliomas
Glycoproteins
Hospitals
Immunohistochemistry
Lung cancer
Medical equipment and supplies industry
Medical test kit industry
Melanoma
Metastasis
Pathology
Physiological aspects
Proteins
Tumors
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Title Tenascin-W is a better cancer biomarker than tenascin-C for most human solid tumors
URI https://www.ncbi.nlm.nih.gov/pubmed/22947174
https://www.proquest.com/docview/1040689294
https://search.proquest.com/docview/1041143957
http://dx.doi.org/10.1186/1472-6890-12-14
https://pubmed.ncbi.nlm.nih.gov/PMC3444373
Volume 12
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