Comparison of the accuracy of methods of computational haplotype inference using a large empirical dataset

• Published in: BMC genetics Vol. 5; no. 1; p. 22
• Main Author: Adkins, Ronald M
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.08.2004; BioMed Central; BMC
• Subjects: Algorithms; Bayes Theorem; Gene Frequency; Genetic Linkage; Haplotypes; Human Growth Hormone - genetics; Humans; Mathematical Computing; Models, Genetic; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Software

Analyses of genetic data at the level of haplotypes provide increased accuracy and power to infer genotype-phenotype correlations and evolutionary history of a locus. However, empirical determination of haplotypes is expensive and laborious. Therefore, several methods of inferring haplotypes from un...