Tobacco Smoking: Risk to Develop Addiction, Chronic Obstructive Pulmonary Disease, and Lung Cancer

• Published in: Recent patents on anti-cancer drug discovery Vol. 14; no. 1; p. 39
• Main Authors: Santoro, Alessia, Tomino, Carlo, Prinzi, Giulia, Lamonaca, Palma, Cardaci, Vittorio, Fini, Massimo, Russo, Patrizia
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2019
• Subjects: Animals; Humans; Lung Neoplasms - chemically induced; Lung Neoplasms - drug therapy; Lung Neoplasms - metabolism; Nicotinic Antagonists - metabolism; Nicotinic Antagonists - pharmacology; Nicotinic Antagonists - therapeutic use; Patents as Topic; Pulmonary Disease, Chronic Obstructive - chemically induced; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - metabolism; Receptors, Nicotinic - metabolism; Risk Factors; Smoking Cessation - methods; Smoking Cessation Agents - metabolism; Smoking Cessation Agents - pharmacology; Smoking Cessation Agents - therapeutic use; Tobacco Smoking - drug therapy; Tobacco Smoking - metabolism; Tobacco Use Disorder - drug therapy; Tobacco Use Disorder - metabolism; lung cancer; nicotine; patent; Addiction; cancer hallmarks; nicotinic receptor; genetic variant; COPD

The morbidity and mortality associated with tobacco smoking is well established. Nicotine is the addictive component of tobacco. Nicotine, through the non-neuronal α7nicotinic receptor, induces cell proliferation, neo-angiogenesis, epithelial to mesenchymal transition, and inhibits drug-induced apop...