Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation

• Published in: Respiratory research Vol. 11; no. 1; p. 30
• Main Authors: Cho, Michael H, Washko, George R, Hoffmann, Thomas J, Criner, Gerard J, Hoffman, Eric A, Martinez, Fernando J, Laird, Nan, Reilly, John J, Silverman, Edwin K
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.03.2010; BioMed Central; BMC
• Subjects: Aged; Cluster Analysis; Demographic aspects; Diagnosis; Emphysema - epidemiology; Emphysema - genetics; Emphysema, Pulmonary; Factor analysis; Female; Genetic aspects; Genetic markers; Genetic Predisposition to Disease - epidemiology; Genetic Predisposition to Disease - genetics; Genetics; Genotype; Genotypes; Heterogeneity; Humans; Identification and classification; Male; Methods; Mutation; Phenotype; Polymorphism, Single Nucleotide - genetics; Prevalence; Risk Assessment; Risk Factors; Studies; United States; Womens health; United States

Numerous studies have demonstrated associations between genetic markers and COPD, but results have been inconsistent. One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity. We selected 31 phenotypic variables and 12...