Microbial community analysis reveals high level phylogenetic alterations in the overall gastrointestinal microbiota of diarrhoea-predominant irritable bowel syndrome sufferers

• Published in: BMC gastroenterology Vol. 9; no. 1; p. 95
• Main Authors: Krogius-Kurikka, Lotta, Lyra, Anna, Malinen, Erja, Aarnikunnas, Johannes, Tuimala, Jarno, Paulin, Lars, Mäkivuokko, Harri, Kajander, Kajsa, Palva, Airi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.12.2009; BioMed Central; BMC
• Subjects: Actinobacteria; Actinobacteria - genetics; Adult; Analysis; Bacteria; Bacteroidetes - genetics; Case-Control Studies; Celiac disease; Cloning; Criminal investigation; Diarrhea - etiology; Diarrhea - microbiology; DNA, Bacterial - analysis; DNA, Bacterial - genetics; Feces - chemistry; Feces - microbiology; Female; Firmicutes; Gastroenterology; Gastrointestinal Tract - microbiology; Gram-Positive Bacteria - genetics; Humans; Irritable bowel syndrome; Irritable Bowel Syndrome - complications; Irritable Bowel Syndrome - microbiology; Male; Medical research; Medicine, Experimental; Microbiology; Middle Aged; Phylogeny; Proteobacteria; Proteobacteria - genetics; Purines; Pyrimidines; Recombinant DNA; RNA; RNA, Bacterial - analysis; RNA, Bacterial - genetics
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/1471-230X-9-95

A growing amount of scientific evidence suggests that microbes are involved in the aetiology of irritable bowel syndrome (IBS), and the gastrointestinal (GI) microbiota of individuals suffering from diarrhoea-predominant IBS (IBS-D) is distinguishable from other IBS-subtypes. In our study, the GI mi...