A central role for cAMP/EPAC/RAP/PI3K/AKT/CREB signaling in LH-induced follicular Pgr expression at medaka ovulation

• Published in: Biology of reproduction Vol. 105; no. 2; pp. 413 - 426
• Main Authors: Ogiwara, Katsueki, Hoyagi, Miyuki, Takahashi, Takayuki
• Format: Journal Article
• Language: English
• Published: United States Society for the Study of Reproduction 01.08.2021; Oxford University Press
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; AKT1 protein; Analysis; Animals; Brefeldin A; Calpain; Cyclic adenylic acid; Cyclic AMP response element-binding protein; EPAC/RAP/PI3K/AKT/CREB signaling; Female; Fish Proteins - antagonists & inhibitors; Fish Proteins - genetics; Fish Proteins - metabolism; Follicles; Fresh water; Gene Expression; Infertility; Kinases; Luteinizing Hormone - metabolism; Matrix metalloproteinase; medaka; Metalloproteinase; Officials and employees; Oryzias - genetics; Oryzias - physiology; Ovulation; Ovulation - genetics; PGR; Pharmaceutical industry; Progestin; Protein kinase A; Proteolysis; RESEARCH ARTICLE; Signal Transduction; teleost; Transcription factors; Uterus; Wortmannin; Japan; Germany; EPAC/RAP/PI3K/AKT/CREB signaling; PGR; teleost; LH; medaka; ovulation

Nuclear progestin receptor (PGR) is a ligand-activated transcription factor that has been identified as a pivotal mediator of many processes associated with ovarian and uterine function, and aberrant control of PGR activity causes infertility and disease including cancer. The essential role of PGR i...