Effects of cisapride on gall bladder emptying, intestinal transit, and serum deoxycholate: a prospective, randomised, double blind, placebo controlled trial

• Published in: Gut Vol. 49; no. 6; pp. 828 - 834
• Main Authors: Veysey, M J, Malcolm, P, Mallet, A I, Jenkins, P J, Besser, G M, Murphy, G M, Dowling, R H
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.12.2001; BMJ; BMJ Publishing Group Ltd; BMJ Publishing Group LTD
• Subjects: Acids; acromegaly; Acromegaly - drug therapy; Adult; Age; Bile; Biological and medical sciences; Bladder; Cholelithiasis - prevention & control; Cholesterol; Cholic Acid - blood; Cisapride; Cisapride - therapeutic use; Constipation - drug therapy; Cross-Over Studies; deoxycholic acid; Deoxycholic Acid - blood; Digestive system; Double-Blind Method; Enzymes; Fasting; Female; gall bladder stones; Gallbladder; Gallbladder Emptying - drug effects; Gallstones; Gastroenterology; Gastrointestinal Agents - therapeutic use; Gastrointestinal Transit - drug effects; Humans; large bowel transit time; Male; Medical sciences; Middle Aged; octreotide; Octreotide - adverse effects; Octreotide - therapeutic use; Octreotide acetate; Pathogenesis; Pharmacology. Drug treatments; Physiological aspects; Prevention; Prospective Studies; Regression Analysis; Rodents; Sludge; Stone; Studies; Ultrasonic imaging; United Kingdom; Human; Cisapride; Digestive system; Gut; Prokinetic agent; Biological activity; Digestive transit; Randomization; Evacuation; Double blind study; Benzamide derivatives; Clinical trial; Gallbladder; Antiemetic

BACKGROUND Octreotide inhibits gall bladder emptying and prolongs intestinal transit. This leads to increases in the proportion of deoxycholic acid in, and cholesterol saturation of, gall bladder bile, factors that contribute to the pathogenesis of octreotide induced gall stones. AIMS To see if an i...