Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue

• Published in: Retrovirology Vol. 9; no. 1; p. 20
• Main Authors: Gonzalez-Perez, Maria Paz, O'Connell, Olivia, Lin, Rongheng, Sullivan, W Matthew, Bell, Jeanne, Simmonds, Peter, Clapham, Paul R
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.03.2012; BioMed Central; BMC
• Subjects: Acquired immune deficiency syndrome; Acquired Immunodeficiency Syndrome - immunology; Acquired Immunodeficiency Syndrome - virology; Adaptation, Biological; AIDS; Brain; Brain - immunology; Brain - virology; CCR5; CD4; Confidence intervals; Dementia; Disease; Entry; Envelope; Health sciences; HIV; HIV Envelope Protein gp120 - chemistry; HIV Envelope Protein gp120 - genetics; HIV-1 - genetics; HIV-1 - growth & development; HIV-1 - pathogenicity; HIV-1 - physiology; Human immunodeficiency virus; Humans; Immune tissue; Macrophage-tropism; Macrophages - virology; Molecular Sequence Data; Neurotropism; Phylogenetics; Selection, Genetic; Sequence Analysis, DNA; Spleen; Statistical methods; Studies; Viral Tropism; Edinburgh Scotland

Transmitted HIV-1 clade B or C R5 viruses have been reported to infect macrophages inefficiently, while other studies have described R5 viruses in late disease with either an enhanced macrophage-tropism or carrying envelopes with an increased positive charge and fitness. In contrast, our previous da...