Polygenic Risk Scores have high diagnostic capacity in ankylosing spondylitis

• Published in: Annals of the rheumatic diseases Vol. 80; no. 9; pp. 1168 - 1174
• Main Authors: Li, Zhixiu, Wu, Xin, Leo, Paul J, De Guzman, Erika, Akkoc, Nurullah, Breban, Maxime, Macfarlane, Gary J, Mahmoudi, Mahdi, Marzo-Ortega, Helena, Anderson, Lisa K, Wheeler, Lawrie, Chou, Chung-Tei, Harrison, Andrew A, Stebbings, Simon, Jones, Gareth T, Bang, So-Young, Wang, Geng, Jamshidi, Ahmadreza, Farhadi, Elham, Song, Jing, Lin, Li, Li, Mengmeng, Wei, James Cheng-Chung, Wright, Margaret J, Lee, MinJae, Wang, Yuqin, Zhan, Jian, Zhang, Jin-San, Wang, Xiaobing, Jin, Zi-Bing, Weisman, Michael H, Gensler, Lianne S, Ward, Michael M, Rahbar, Mohammad Hossein, Diekman, Laura, Kim, Tae-Hwan, Reveille, John D, Wordsworth, Bryan Paul, Xu, Huji, Brown, Matthew A, Yin, Jian, Jiang, Lei, Zhou, Lin, Li, Ting, Wang, Qingwen, Li, Tianwang, Gao, Guanmin, Xu, Shengqian, Xiao, Weiguo, Shen, Hui, Zhou, Jingguo, You, Yuquan, Zhao, Dongbao, Cai, Qing, Dai, Shengming, He, Lan, Zhu, Ping, Jiang, Zhenyu, Xu, Jian, Dai, Lie, Li, Yang, Ding, Feng, Zhu, Xiaochun, Liu, Chongyang, He, Dongyi, Zhang, Liyun, Li, Zhijun, Zhao, Futao, Xu, Hanshi, Wang, Niansong, Wang, Youlian, Jiang, Lindi, Zhang, Yu, Chen, Jinwei, Cheng, Fang, Zhang, Zhiyi, Mei, Yifang, Lv, Liangjing, Dong, Lingli, Yang, Jing, Li, Yinong, Wang, Xiaodong, Li, Xiaofeng, Sun, Hongsheng, Long, Xianming, Zhang, Xiao, Yu, Qinghong, Kong, Xiaodan, Zheng, Yi, Zhang, Miaojia, Tao, Yi, Li, Yisha, Duan, Xinwang, Wei, Qianghua, Wang, Xiaofei, Han, Jie, Mu, Rong, Lin, Yiping, Zhu, Jian, Chen, Xiaoyuan
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and European League Against Rheumatism 01.09.2021; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: ankylosing; Ankylosing spondylitis; Arthritis; Back pain; C-reactive protein; Chronic pain; Diagnostic tests; Disease; genetic; Genetics; Genome-wide association studies; Genomes; Health risk assessment; Human genetics; Human health and pathology; Life Sciences; low back pain; Magnetic resonance imaging; Minority & ethnic groups; polymorphism; Population; Populations and Evolution; Proteins; Quality control; Rhumatology and musculoskeletal system; Shellfish; Software; spondylitis; Spondyloarthritis; genetic; spondylitis; magnetic resonance imaging; polymorphism; ankylosing; low back pain

ObjectiveWe sought to test the hypothesis that Polygenic Risk Scores (PRSs) have strong capacity to discriminate cases of ankylosing spondylitis (AS) from healthy controls and individuals in the community with chronic back pain.MethodsPRSs were developed and validated in individuals of European and...