Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation

• Published in: BMC neuroscience Vol. 7; no. 1; p. 77
• Main Authors: Plümpe, Tobias, Ehninger, Dan, Steiner, Barbara, Klempin, Friederike, Jessberger, Sebastian, Brandt, Moritz, Römer, Benedikt, Rodriguez, Gerardo Ramirez, Kronenberg, Golo, Kempermann, Gerd
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.11.2006; BioMed Central; BMC
• Subjects: Age Factors; Animals; Astrocytes - metabolism; Behavior, Animal; Blotting, Western - methods; Bromodeoxyuridine - metabolism; Cell Count - methods; Cell Proliferation; Cell Survival - physiology; Dendrites - physiology; Female; Hippocampus - cytology; Immunohistochemistry - methods; In Situ Nick-End Labeling - methods; Kainic Acid; Maze Learning - physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins - metabolism; Neurons - cytology; Neurons - physiology; Neuropeptides - metabolism; Organogenesis - physiology; Physical Conditioning, Animal - physiology; Seizures - chemically induced; Seizures - pathology

In the course of adult hippocampal neurogenesis most regulation takes place during the phase of doublecortin (DCX) expression, either as pro-proliferative effect on precursor cells or as survival-promoting effect on postmitotic cells. We here obtained quantitative data about the proliferative popula...