Management of persistent anal canal carcinoma after combined-modality therapy: a clinical review
Anal canal carcinoma is a rare gastro-intestinal cancer. Radiochemotherapy is the recommended primary treatment for patients with non-metastatic carcinoma; surgery is generally reserved for persistent or recurrent disease. Follow-up and surveillance after primary treatment is paramount to classify p...
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| Published in | Radiation oncology (London, England) Vol. 9; no. 1; p. 39 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BioMed Central Ltd
28.01.2014
BioMed Central |
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| Abstract | Anal canal carcinoma is a rare gastro-intestinal cancer. Radiochemotherapy is the recommended primary treatment for patients with non-metastatic carcinoma; surgery is generally reserved for persistent or recurrent disease. Follow-up and surveillance after primary treatment is paramount to classify patients in those with complete remission, persistent or progressive disease. Locally persistent disease represents a clinically significant problem and its management remains subject of some controversy.The aim of this systematic review is to summarise recommendations for the primary treatment of anal canal carcinoma, to focus on the optimal time to consider residual disease as genuine persistence to proceed with salvage treatment, and to discern how this analysis might inform future clinical trials in management in this class of patients. |
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| AbstractList | Anal canal carcinoma is a rare gastro-intestinal cancer. Radiochemotherapy is the recommended primary treatment for patients with non-metastatic carcinoma; surgery is generally reserved for persistent or recurrent disease. Follow-up and surveillance after primary treatment is paramount to classify patients in those with complete remission, persistent or progressive disease. Locally persistent disease represents a clinically significant problem and its management remains subject of some controversy. Anal canal carcinoma is a rare gastro-intestinal cancer. Radiochemotherapy is the recommended primary treatment for patients with non-metastatic carcinoma; surgery is generally reserved for persistent or recurrent disease. Follow-up and surveillance after primary treatment is paramount to classify patients in those with complete remission, persistent or progressive disease. Locally persistent disease represents a clinically significant problem and its management remains subject of some controversy.The aim of this systematic review is to summarise recommendations for the primary treatment of anal canal carcinoma, to focus on the optimal time to consider residual disease as genuine persistence to proceed with salvage treatment, and to discern how this analysis might inform future clinical trials in management in this class of patients. Anal canal carcinoma is a rare gastro-intestinal cancer. Radiochemotherapy is the recommended primary treatment for patients with non-metastatic carcinoma; surgery is generally reserved for persistent or recurrent disease. Follow-up and surveillance after primary treatment is paramount to classify patients in those with complete remission, persistent or progressive disease. Locally persistent disease represents a clinically significant problem and its management remains subject of some controversy.The aim of this systematic review is to summarise recommendations for the primary treatment of anal canal carcinoma, to focus on the optimal time to consider residual disease as genuine persistence to proceed with salvage treatment, and to discern how this analysis might inform future clinical trials in management in this class of patients.Anal canal carcinoma is a rare gastro-intestinal cancer. Radiochemotherapy is the recommended primary treatment for patients with non-metastatic carcinoma; surgery is generally reserved for persistent or recurrent disease. Follow-up and surveillance after primary treatment is paramount to classify patients in those with complete remission, persistent or progressive disease. Locally persistent disease represents a clinically significant problem and its management remains subject of some controversy.The aim of this systematic review is to summarise recommendations for the primary treatment of anal canal carcinoma, to focus on the optimal time to consider residual disease as genuine persistence to proceed with salvage treatment, and to discern how this analysis might inform future clinical trials in management in this class of patients. Doc number: 39 Abstract: Anal canal carcinoma is a rare gastro-intestinal cancer. Radiochemotherapy is the recommended primary treatment for patients with non-metastatic carcinoma; surgery is generally reserved for persistent or recurrent disease. Follow-up and surveillance after primary treatment is paramount to classify patients in those with complete remission, persistent or progressive disease. Locally persistent disease represents a clinically significant problem and its management remains subject of some controversy. The aim of this systematic review is to summarise recommendations for the primary treatment of anal canal carcinoma, to focus on the optimal time to consider residual disease as genuine persistence to proceed with salvage treatment, and to discern how this analysis might inform future clinical trials in management in this class of patients. Anal canal carcinoma is a rare gastro-intestinal cancer. Radiochemotherapy is the recommended primary treatment for patients with non-metastatic carcinoma; surgery is generally reserved for persistent or recurrent disease. Follow-up and surveillance after primary treatment is paramount to classify patients in those with complete remission, persistent or progressive disease. Locally persistent disease represents a clinically significant problem and its management remains subject of some controversy. The aim of this systematic review is to summarise recommendations for the primary treatment of anal canal carcinoma, to focus on the optimal time to consider residual disease as genuine persistence to proceed with salvage treatment, and to discern how this analysis might inform future clinical trials in management in this class of patients. |
| ArticleNumber | 39 |
| Audience | Academic |
| Author | Tombolini, Vincenzo Raffetto, Nicola Musio, Daniela De Felice, Francesca |
| AuthorAffiliation | 1 Department of radiological, oncological and anatomo-pathological science, “Sapienza” University, Viale Regina Elena, Rome, Italy |
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| Author_xml | – sequence: 1 givenname: Daniela surname: Musio fullname: Musio, Daniela – sequence: 2 givenname: Francesca surname: De Felice fullname: De Felice, Francesca – sequence: 3 givenname: Nicola surname: Raffetto fullname: Raffetto, Nicola – sequence: 4 givenname: Vincenzo surname: Tombolini fullname: Tombolini, Vincenzo |
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| CitedBy_id | crossref_primary_10_1016_j_brachy_2016_08_003 crossref_primary_10_1002_pbc_25988 crossref_primary_10_1007_s00384_018_03225_7 crossref_primary_10_1016_j_euf_2019_06_002 crossref_primary_10_1016_j_clcc_2020_03_005 crossref_primary_10_1586_14737140_2014_919861 crossref_primary_10_3238_arztebl_2015_0243 crossref_primary_10_1016_j_tranon_2022_101590 |
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| Copyright | COPYRIGHT 2014 BioMed Central Ltd. 2014 Musio et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Copyright © 2014 Musio et al.; licensee BioMed Central Ltd. 2014 Musio et al.; licensee BioMed Central Ltd. |
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| SubjectTerms | Anus Neoplasms - pathology Anus Neoplasms - therapy Combined Modality Therapy Humans Neoplasm Recurrence, Local - therapy Neoplasm, Residual Practice Guidelines as Topic Radiotherapy - methods Radiotherapy - standards Review Salvage Therapy - methods Salvage Therapy - standards Treatment Failure |
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| Title | Management of persistent anal canal carcinoma after combined-modality therapy: a clinical review |
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