Novel therapeutic agents in clinical development for systemic lupus erythematosus

Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the comple...

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Published inBMC medicine Vol. 11; no. 1; p. 120
Main Authors Jordan, Natasha, Lutalo, Pamela M K, D'Cruz, David P
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 03.05.2013
BioMed Central
Subjects
Angiogenesis Inhibitors - pharmacology
Angiogenesis Inhibitors - therapeutic use
Animals
Autoimmune diseases
B cells
B-Lymphocytes - drug effects
B-Lymphocytes - immunology
Biological Factors - pharmacology
Biological Factors - therapeutic use
Biological products industry
Biological response modifiers
Care and treatment
Clinical trials
Clinical Trials as Topic - trends
Dosage and administration
Drug therapy
Humans
Immune system
Immunosuppressive Agents - pharmacology
Immunosuppressive Agents - therapeutic use
Interferon
Kidney diseases
Lupus
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - immunology
Monoclonal antibodies
Mortality
Nephritis
Product development
Review
Systemic lupus erythematosus
T cells
Online AccessGet full text

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Abstract Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the complexity of SLE immunopathogenesis has evolved over the past decade and has led to the testing of several biologic agents in clinical trials. There is a clear need for new therapeutic agents that overcome these issues, and biologic agents offer exciting prospects as future SLE therapies.An array of promising new therapies are currently emerging or are under development including B-cell depletion therapies, agents targeting B-cell survival factors, blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonal antibodies against interleukin-6 and interferon-α.
AbstractList Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the complexity of SLE immunopathogenesis has evolved over the past decade and has led to the testing of several biologic agents in clinical trials. There is a clear need for new therapeutic agents that overcome these issues, and biologic agents offer exciting prospects as future SLE therapies.An array of promising new therapies are currently emerging or are under development including B-cell depletion therapies, agents targeting B-cell survival factors, blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonal antibodies against interleukin-6 and interferon-α.
Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the complexity of SLE immunopathogenesis has evolved over the past decade and has led to the testing of several biologic agents in clinical trials. There is a clear need for new therapeutic agents that overcome these issues, and biologic agents offer exciting prospects as future SLE therapies. An array of promising new therapies are currently emerging or are under development including B-cell depletion therapies, agents targeting B-cell survival factors, blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonal antibodies against interleukin-6 and interferon-α.
Conventional immunosuppressive therapies have radically transformed patient survivalin systemic lupus erythematosus (SLE), but their use is associated with considerabletoxicity and a substantial proportion of patients remain refractory to treatment. Amore comprehensive understanding of the complexity of SLE immunopathogenesis hasevolved over the past decade and has led to the testing of several biologic agents inclinical trials. There is a clear need for new therapeutic agents that overcome theseissues, and biologic agents offer exciting prospects as future SLE therapies. An array of promising new therapies are currently emerging or are under developmentincluding B-cell depletion therapies, agents targeting B-cell survival factors,blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonalantibodies against interleukin-6 and interferon-[alpha]. Keywords: Lupus nephritis, B-cell depletion, BLys, T-cell co-stimulation, Interferon-[alpha], SLE
Doc number: 120 Abstract: Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the complexity of SLE immunopathogenesis has evolved over the past decade and has led to the testing of several biologic agents in clinical trials. There is a clear need for new therapeutic agents that overcome these issues, and biologic agents offer exciting prospects as future SLE therapies. An array of promising new therapies are currently emerging or are under development including B-cell depletion therapies, agents targeting B-cell survival factors, blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonal antibodies against interleukin-6 and interferon-α.
Conventional immunosuppressive therapies have radically transformed patient survivalin systemic lupus erythematosus (SLE), but their use is associated with considerabletoxicity and a substantial proportion of patients remain refractory to treatment. Amore comprehensive understanding of the complexity of SLE immunopathogenesis hasevolved over the past decade and has led to the testing of several biologic agents inclinical trials. There is a clear need for new therapeutic agents that overcome theseissues, and biologic agents offer exciting prospects as future SLE therapies.
Abstract Conventional immunosuppressive therapies have radically transformed patient survivalin systemic lupus erythematosus (SLE), but their use is associated with considerabletoxicity and a substantial proportion of patients remain refractory to treatment. Amore comprehensive understanding of the complexity of SLE immunopathogenesis hasevolved over the past decade and has led to the testing of several biologic agents inclinical trials. There is a clear need for new therapeutic agents that overcome theseissues, and biologic agents offer exciting prospects as future SLE therapies. An array of promising new therapies are currently emerging or are under developmentincluding B-cell depletion therapies, agents targeting B-cell survival factors,blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonalantibodies against interleukin-6 and interferon-α.
ArticleNumber 120
Audience Academic
Author Jordan, Natasha
D'Cruz, David P
Lutalo, Pamela M K
AuthorAffiliation 1 Louise Coote Lupus Unit, St Thomas’ Hospital, Westminster Bridge Road, London, SE1 7EH, UK
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  givenname: Natasha
  surname: Jordan
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  givenname: Pamela M K
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  fullname: Lutalo, Pamela M K
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  surname: D'Cruz
  fullname: D'Cruz, David P
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23642011$$D View this record in MEDLINE/PubMed
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Copyright © 2013 Jordan et al.; licensee BioMed Central Ltd. 2013 Jordan et al.; licensee BioMed Central Ltd.
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Snippet Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with...
Abstract Conventional immunosuppressive therapies have radically transformed patient survivalin systemic lupus erythematosus (SLE), but their use is associated...
Conventional immunosuppressive therapies have radically transformed patient survivalin systemic lupus erythematosus (SLE), but their use is associated with...
Doc number: 120 Abstract: Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their...
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StartPage 120
SubjectTerms Angiogenesis Inhibitors - pharmacology
Angiogenesis Inhibitors - therapeutic use
Animals
Autoimmune diseases
B cells
B-Lymphocytes - drug effects
B-Lymphocytes - immunology
Biological Factors - pharmacology
Biological Factors - therapeutic use
Biological products industry
Biological response modifiers
Care and treatment
Clinical trials
Clinical Trials as Topic - trends
Dosage and administration
Drug therapy
Humans
Immune system
Immunosuppressive Agents - pharmacology
Immunosuppressive Agents - therapeutic use
Interferon
Kidney diseases
Lupus
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - immunology
Monoclonal antibodies
Mortality
Nephritis
Product development
Review
Systemic lupus erythematosus
T cells
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Title Novel therapeutic agents in clinical development for systemic lupus erythematosus
URI https://www.ncbi.nlm.nih.gov/pubmed/23642011
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http://dx.doi.org/10.1186/1741-7015-11-120
https://pubmed.ncbi.nlm.nih.gov/PMC3667088
Volume 11
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