Novel therapeutic agents in clinical development for systemic lupus erythematosus
Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the comple...
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Published in | BMC medicine Vol. 11; no. 1; p. 120 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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03.05.2013
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Abstract | Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the complexity of SLE immunopathogenesis has evolved over the past decade and has led to the testing of several biologic agents in clinical trials. There is a clear need for new therapeutic agents that overcome these issues, and biologic agents offer exciting prospects as future SLE therapies.An array of promising new therapies are currently emerging or are under development including B-cell depletion therapies, agents targeting B-cell survival factors, blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonal antibodies against interleukin-6 and interferon-α. |
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AbstractList | Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the complexity of SLE immunopathogenesis has evolved over the past decade and has led to the testing of several biologic agents in clinical trials. There is a clear need for new therapeutic agents that overcome these issues, and biologic agents offer exciting prospects as future SLE therapies.An array of promising new therapies are currently emerging or are under development including B-cell depletion therapies, agents targeting B-cell survival factors, blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonal antibodies against interleukin-6 and interferon-α. Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the complexity of SLE immunopathogenesis has evolved over the past decade and has led to the testing of several biologic agents in clinical trials. There is a clear need for new therapeutic agents that overcome these issues, and biologic agents offer exciting prospects as future SLE therapies. An array of promising new therapies are currently emerging or are under development including B-cell depletion therapies, agents targeting B-cell survival factors, blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonal antibodies against interleukin-6 and interferon-α. Conventional immunosuppressive therapies have radically transformed patient survivalin systemic lupus erythematosus (SLE), but their use is associated with considerabletoxicity and a substantial proportion of patients remain refractory to treatment. Amore comprehensive understanding of the complexity of SLE immunopathogenesis hasevolved over the past decade and has led to the testing of several biologic agents inclinical trials. There is a clear need for new therapeutic agents that overcome theseissues, and biologic agents offer exciting prospects as future SLE therapies. An array of promising new therapies are currently emerging or are under developmentincluding B-cell depletion therapies, agents targeting B-cell survival factors,blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonalantibodies against interleukin-6 and interferon-[alpha]. Keywords: Lupus nephritis, B-cell depletion, BLys, T-cell co-stimulation, Interferon-[alpha], SLE Doc number: 120 Abstract: Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the complexity of SLE immunopathogenesis has evolved over the past decade and has led to the testing of several biologic agents in clinical trials. There is a clear need for new therapeutic agents that overcome these issues, and biologic agents offer exciting prospects as future SLE therapies. An array of promising new therapies are currently emerging or are under development including B-cell depletion therapies, agents targeting B-cell survival factors, blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonal antibodies against interleukin-6 and interferon-α. Conventional immunosuppressive therapies have radically transformed patient survivalin systemic lupus erythematosus (SLE), but their use is associated with considerabletoxicity and a substantial proportion of patients remain refractory to treatment. Amore comprehensive understanding of the complexity of SLE immunopathogenesis hasevolved over the past decade and has led to the testing of several biologic agents inclinical trials. There is a clear need for new therapeutic agents that overcome theseissues, and biologic agents offer exciting prospects as future SLE therapies. Abstract Conventional immunosuppressive therapies have radically transformed patient survivalin systemic lupus erythematosus (SLE), but their use is associated with considerabletoxicity and a substantial proportion of patients remain refractory to treatment. Amore comprehensive understanding of the complexity of SLE immunopathogenesis hasevolved over the past decade and has led to the testing of several biologic agents inclinical trials. There is a clear need for new therapeutic agents that overcome theseissues, and biologic agents offer exciting prospects as future SLE therapies. An array of promising new therapies are currently emerging or are under developmentincluding B-cell depletion therapies, agents targeting B-cell survival factors,blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonalantibodies against interleukin-6 and interferon-α. |
ArticleNumber | 120 |
Audience | Academic |
Author | Jordan, Natasha D'Cruz, David P Lutalo, Pamela M K |
AuthorAffiliation | 1 Louise Coote Lupus Unit, St Thomas’ Hospital, Westminster Bridge Road, London, SE1 7EH, UK |
AuthorAffiliation_xml | – name: 1 Louise Coote Lupus Unit, St Thomas’ Hospital, Westminster Bridge Road, London, SE1 7EH, UK |
Author_xml | – sequence: 1 givenname: Natasha surname: Jordan fullname: Jordan, Natasha organization: Louise Coote Lupus Unit, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK – sequence: 2 givenname: Pamela M K surname: Lutalo fullname: Lutalo, Pamela M K – sequence: 3 givenname: David P surname: D'Cruz fullname: D'Cruz, David P |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23642011$$D View this record in MEDLINE/PubMed |
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Copyright | COPYRIGHT 2013 BioMed Central Ltd. 2013 Jordan et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2013 Jordan et al.; licensee BioMed Central Ltd. 2013 Jordan et al.; licensee BioMed Central Ltd. |
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Snippet | Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with... Abstract Conventional immunosuppressive therapies have radically transformed patient survivalin systemic lupus erythematosus (SLE), but their use is associated... Conventional immunosuppressive therapies have radically transformed patient survivalin systemic lupus erythematosus (SLE), but their use is associated with... Doc number: 120 Abstract: Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their... |
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SubjectTerms | Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Animals Autoimmune diseases B cells B-Lymphocytes - drug effects B-Lymphocytes - immunology Biological Factors - pharmacology Biological Factors - therapeutic use Biological products industry Biological response modifiers Care and treatment Clinical trials Clinical Trials as Topic - trends Dosage and administration Drug therapy Humans Immune system Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Interferon Kidney diseases Lupus Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - immunology Monoclonal antibodies Mortality Nephritis Product development Review Systemic lupus erythematosus T cells |
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Title | Novel therapeutic agents in clinical development for systemic lupus erythematosus |
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