Human papilloma viruses and cervical tumours: mapping of integration sites and analysis of adjacent cellular sequences

• Published in: BMC cancer Vol. 2; no. 1; p. 24
• Main Authors: Klimov, Eugene, Vinokourova, Svetlana, Moisjak, Elena, Rakhmanaliev, Elian, Kobseva, Vera, Laimins, Laimonis, Kisseljov, Fjodor, Sulimova, Galina
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.10.2002; BioMed Central; BMC
• Subjects: Binding Sites - genetics; Chromosome Mapping; Databases, Nucleic Acid; DNA, Complementary - chemistry; DNA, Complementary - genetics; Female; Genetic Markers; Human papillomavirus; Humans; Molecular Sequence Data; Papillomaviridae - genetics; Papillomavirus Infections - genetics; Papillomavirus Infections - virology; Radiation Hybrid Mapping; Sequence Analysis, DNA; Tumor Virus Infections - genetics; Tumor Virus Infections - virology; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - virology; Virus Integration - genetics

In cervical tumours the integration of human papilloma viruses (HPV) transcripts often results in the generation of transcripts that consist of hybrids of viral and cellular sequences. Mapping data using a variety of techniques has demonstrated that HPV integration occurred without obvious specifici...