Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation

• Published in: Critical care (London, England) Vol. 14; no. 2; p. R61
• Main Authors: Kim, Oh Yoen, Monsel, Antoine, Bertrand, Michèle, Coriat, Pierre, Cavaillon, Jean-Marc, Adib-Conquy, Minou
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.04.2010; National Library of Medicine - MEDLINE Abstracts; BioMed Central
• Subjects: Aged; Aorta, Abdominal - immunology; Aorta, Abdominal - surgery; Carotid Arteries - immunology; Carotid Arteries - surgery; Case-Control Studies; Development and progression; Down-Regulation - immunology; Female; Flow Cytometry; Gene expression; Gene Expression - immunology; Genetic aspects; Genetic regulation; HLA class II antigens; HLA-DR Antigens - biosynthesis; HLA-DR Antigens - immunology; Humans; Inflammation; Lipopolysaccharide Receptors - metabolism; Male; Middle Aged; Monocytes; Monocytes - cytology; Monocytes - immunology; Monocytes - metabolism; Observations; Physiological aspects; Polymerase Chain Reaction - methods; Properties; Systemic Inflammatory Response Syndrome - immunology; Systemic Inflammatory Response Syndrome - metabolism; France

Decreased expression of human leukocyte antigen class II (HLA-DR) on monocytes is a hallmark of altered immune status in patients with a systemic inflammatory response syndrome (SIRS). So far, the analyses were mainly performed without taking into account monocytes subpopulations. We studied this mo...