Identifying positive selection candidate loci for high-altitude adaptation in Andean populations

• Published in: Human genomics Vol. 4; no. 2; pp. 79 - 90
• Main Authors: Bigham, Abigail W, Mao, Xianyun, Mei, Rui, Brutsaert, Tom, Wilson, Megan J, Julian, Colleen Glyde, Parra, Esteban J, Akey, Joshua M, Moore, Lorna G, Shriver, Mark D
• Format: Journal Article
• Language: English
• Published: England BioMed Central 01.12.2009; BioMed Central Ltd; BMC
• Subjects: Altitude; altitude adaptation; Chromosomes; Genes; genome scan; Genome-Wide Association Study; Genomes; Haplotypes; Humans; Hypoxia - genetics; Hypoxia - metabolism; Indians, North American - genetics; Kinases; Native Americans; Polymorphism, Single Nucleotide; Population; positive selection; Primary Research; Selection, Genetic; Statistics; Studies; Veins & arteries

High-altitude environments (>2,500 m) provide scientists with a natural laboratory to study the physiological and genetic effects of low ambient oxygen tension on human populations. One approach to understanding how life at high altitude has affected human metabolism is to survey genome-wide data...