Type I interferons in host defence and inflammatory diseases

• Published in: Lupus science & medicine Vol. 6; no. 1; p. e000336
• Main Authors: Crow, Mary K., Ronnblom, Lars
• Format: Journal Article
• Language: English
• Published: England Lupus Foundation of America 01.01.2019; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Antigens; Apoptosis; Arthritis; Autoimmune diseases; Cytokines; Dendritic cells; Deoxyribonucleic acid; Disease; DNA; Inflammatory diseases; Interferon; Kinases; Lupus; Lymphocytes; Mitochondrial DNA; Pathogenesis; Patients; Review; Sensors; systemic lupus erythematosus; Tumor necrosis factor-TNF; Viral infections; autoimmune diseases; interferon; systemic lupus erythematosus

Type I interferons (IFN) can have dual and opposing roles in immunity, with effects that are beneficial or detrimental to the individual depending on whether IFN pathway activation is transient or sustained. Determinants of IFN production and its functional consequences include the nature of the mic...