Differential sequential patterns supporting insulin therapy of new-onset type 1 diabetes

• Published in: Biomedical engineering online Vol. 14; no. 1; p. 13
• Main Authors: Deja, Rafał, Froelich, Wojciech, Deja, GraŻyna
• Format: Journal Article
• Language: English
• Published: London BioMed Central 21.02.2015; BioMed Central Ltd
• Subjects: Algorithms; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical Engineering/Biotechnology; Biotechnology; Blood Glucose - analysis; Circadian Rhythm; Data Mining; Datasets as Topic; Decision Support Systems, Clinical; Decision Support Techniques; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - physiopathology; Dose-Response Relationship, Drug; Drug Administration Schedule; Eating; Engineering; Glucagon - metabolism; Humans; Insulin - administration & dosage; Insulin - metabolism; Insulin - therapeutic use; Insulin Secretion; Pancreas - metabolism; Secretory Rate; Sleep; Data mining; Diabetes mellitus; Medical patterns
• ISSN: 1475-925X; 1475-925X
• DOI: 10.1186/s12938-015-0004-x

Background In spite of numerous research efforts on supporting the therapy of diabetes mellitus, the subject still involves challenges and creates active interest among researchers. In this paper, a decision support tool is presented for setting insulin therapy in new-onset type 1 diabetes. Methods The concept of differential sequential patterns (DSPs) is introduced with the aim of representing deviations in the patient’s blood glucose level (BGL) and the amount of insulin injections administered. The decision support tool is created using data mining algorithms for discovering sequential patterns. Results By using the DSPs, it is possible to support the physician’s decisionmaking concerning changing the treatment (i.e., whether to increase or decrease the insulin dosage). The other contributions of the paper are an algorithm for generating DSPs and a new method for evaluating nocturnal glycaemia. The proposed qualitative evaluation of nocturnal glycaemia improves the generalization capabilities of the DSPs. Conclusions The usefulness of the proposed approach was evident in the results of experiments in which juvenile diabetic patients actual data were used. It was confirmed that the proposed DSPs can be used to guide the therapy of numerous juvenile patients with type 1 diabetes.