BLAST+: architecture and applications

• Published in: BMC bioinformatics Vol. 10; no. 1; p. 421
• Main Authors: Camacho, Christiam, Coulouris, George, Avagyan, Vahram, Ma, Ning, Papadopoulos, Jason, Bealer, Kevin, Madden, Thomas L
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.12.2009; BioMed Central; BMC
• Subjects: Applications software; Bioinformatics; Chromosomes; Computational biology; Computational Biology - methods; Databases, Genetic; Gene expression; Sequence Alignment; Software; United States

Sequence similarity searching is a very important bioinformatics task. While Basic Local Alignment Search Tool (BLAST) outperforms exact methods through its use of heuristics, the speed of the current BLAST software is suboptimal for very long queries or database sequences. There are also some short...