Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions

• Published in: Journal for immunotherapy of cancer Vol. 8; no. 2; p. e001054
• Main Authors: Russick, Jules, Joubert, Pierre-Emmanuel, Gillard-Bocquet, Mélanie, Torset, Carine, Meylan, Maxime, Petitprez, Florent, Dragon-Durey, Marie-Agnes, Marmier, Solenne, Varthaman, Aditi, Josseaume, Nathalie, Germain, Claire, Goc, Jérémy, Dieu-Nosjean, Marie-Caroline, Validire, Pierre, Fournel, Ludovic, Zitvogel, Laurence, Bindea, Gabriela, Lupo, Audrey, Damotte, Diane, Alifano, Marco, Cremer, Isabelle
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd 16.10.2020; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Basic Tumor Immunology; biomarkers; Biomarkers, Tumor; Cancer; Chemokines; Cloning; CTLA-4 antigen; Cytotoxicity; Flow cytometry; Gene expression; Hospitals; Humans; Immunotherapy; Killer Cells, Natural; Life Sciences; Ligands; Lung cancer; lung neoplasms; Lymphocytes; Natural Killer T-Cells; Software; Thoracic surgery; Transcriptome; tumor; Tumor Microenvironment; Tumor necrosis factor-TNF; France; United States > US; California; CTLA-4 antigen; tumor microenvironment; lung neoplasms; biomarkers; tumor; Natural Killer T-Cells

BackgroundNatural killer (NK) cells play a crucial role in tumor immunosurveillance through their cytotoxic effector functions and their capacity to interact with other immune cells to build a coordinated antitumor immune response. Emerging data reveal NK cell dysfunction within the tumor microenvir...