A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects

• Published in: Annals of the rheumatic diseases Vol. 70; no. 12; pp. 2134 - 2139
• Main Authors: Terao, Chikashi, Ohmura, Koichiro, Kochi, Yuta, Ikari, Katsunori, Maruya, Etsuko, Katayama, Masaki, Shimada, Kota, Murasawa, Akira, Honjo, Shigeru, Takasugi, Kiyoshi, Matsuo, Keitaro, Tajima, Kazuo, Suzuki, Akari, Yamamoto, Kazuhiko, Momohara, Shigeki, Yamanaka, Hisashi, Yamada, Ryo, Saji, Hiroo, Matsuda, Fumihiko, Mimori, Tsuneyo
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and European League Against Rheumatism 01.12.2011; BMJ Publishing Group; Elsevier Limited
• Subjects: Adult; Aged; Arthritis, Rheumatoid - genetics; Autoantibodies - blood; Biological and medical sciences; Case-Control Studies; Consortia; Deoxyribonucleic acid; Diseases of the osteoarticular system; DNA; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genetic testing; Genotype; Histocompatibility Testing - methods; HLA-DRB1 Chains - genetics; Hospitals; Humans; Inflammatory joint diseases; Laboratories; Male; Medical sciences; Middle Aged; Peptides, Cyclic - immunology; Rheumatoid arthritis; Software; Statistical analysis; Studies; Japan; Human; Immunopathology; HLA-System; Allele; Chronic; Multiple; Rheumatoid arthritis; Diseases of the osteoarticular system; Rheumatology; Autoimmune disease; Inflammatory joint disease

Background HLA-DRB1 is associated with rheumatoid arthritis (RA). However, it has recently been suggested that HLA-DRB1 is only associated with patients with RA who have anticitrullinated peptide/protein antibodies (ACPA), which are specific to RA. Objective To elucidate whether specific HLA-DR alle...