Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells

• Published in: Journal for immunotherapy of cancer Vol. 10; no. 2; p. e003663
• Main Authors: Bai, Xiaowu, Wong, Chi Chun, Pan, Yasi, Chen, Huarong, Liu, Weixin, Zhai, Jianning, Kang, Wei, Shi, Yu, Yamamoto, Masami, Tsukamoto, Tetsuya, Nomura, Sachiyo, Chiu, Philip, Yu, Jun, Kwok-wai Ng, Enders
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd 01.02.2022; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Animals; Basic Tumor Immunology; Cancer; Cell Line, Tumor; Cohort Studies; CRISPR; Cytokines; Dendritic cells; Dendritic Cells - immunology; Ethics; Female; Flow cytometry; Gastric cancer; Gene expression; Humans; Immunotherapy; Immunotherapy - methods; Male; Mice; Mortality; Plasmids; Proteins; Reagents; RNA-Binding Proteins - metabolism; Stomach Neoplasms - immunology; Stomach Neoplasms - mortality; Survival Analysis; Tumors; United States > US; China; Germany; dendritic cells; immunotherapy

BackgroundGastric cancer (GC) is one of the most common cancer worldwide. We analyzed the expression of m6A regulatory genes in GC cohorts and revealed that YTHDF1 was uniquely upregulated in GC as compared with adjacent normal tissues. In this study, we analyzed the role of YTHDF1 in GC cells and m...