Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma

• Published in: Journal for immunotherapy of cancer Vol. 10; no. 2; p. e003534
• Main Authors: Yang, Lei, He, Yun-Ting, Dong, Song, Wei, Xue-Wu, Chen, Zhi-Hong, Zhang, Bo, Chen, Wei-Dong, Yang, Xiao-Rong, Wang, Fen, Shang, Xue-Meng, Zhong, Wen-Zhao, Wu, Yi-Long, Zhou, Qing
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd 01.01.2022; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Adenocarcinoma of Lung - genetics; Adenocarcinoma of Lung - pathology; Biomarkers, Tumor - metabolism; Cancer; Cancer therapies; Chemotherapy; Cytokines; Epidermal growth factor; ErbB Receptors - genetics; Female; Fibroblasts; Genes; Humans; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Immunotherapy; Immunotherapy - methods; Immunotherapy Biomarkers; Kinases; Lung cancer; lung neoplasms; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Lymphocytes; Male; Mutation; Neutrophils; Ontology; Patients; Prognosis; Single-Cell Analysis - methods; Transcriptome - genetics; Tumor Microenvironment; lung neoplasms; immunotherapy; tumor microenvironment

BackgroundsImmunotherapy is less effective in patients with epidermal growth factor receptor (EGFR) mutant non-small-cell lung cancer (NSCLC). Lower programmed cell death-ligand 1 (PD-L1) expression and tumor mutation burden (TMB) are reported to be the underlying mechanism. Being another important...