Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population

• Published in: Occupational and environmental medicine (London, England) Vol. 58; no. 3; pp. 172 - 177
• Main Authors: Sala, M, Sunyer, J, Herrero, C, To-Figueras, J, Grimalt, J
• Format: Journal Article Book Review
• Language: English
• Published: London BMJ Publishing Group Ltd 01.03.2001; BMJ Publishing Group; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Adolescent; Adult; Aged; Alanine Transaminase - blood; Alcohol drinking; Biological and medical sciences; Biological markers; Biomarkers - blood; Chemical and Drug Induced Liver Injury; Chemical and industrial products toxicology. Toxic occupational diseases; Contaminants; Dioxins; environmental exposure; Environmental Pollutants - blood; Enzymes; Female; gamma-Glutamyltransferase - blood; Gas chromatography; Hexachlorobenzene; Hexachlorobenzene - adverse effects; Hexachlorobenzene - blood; Hormones; Humans; Linear Models; Liver; Liver Diseases - enzymology; liver enzymes; Liver function; Male; Medical sciences; Men; Middle Aged; Organic compounds; Organochlorine compounds; PCB; Polychlorinated biphenyls; Polychlorinated Biphenyls - blood; Regression Analysis; Review; Reviews; Rural populations; Spain; Thyroid; Thyroid Diseases - chemically induced; Thyroid Diseases - enzymology; Thyroid hormones; Thyrotropin - blood; Thyroxine - blood; Toxicology; Turkey; Various organic compounds; Human; Liver function; Pollutant; Activity concentration relation; Organochlorine compounds; Toxicity; Liver; Environment; Thyroid hormone; Thyroid gland; Polychlorobiphenyl

OBJECTIVES Hexachlorobenzene (HCB) is a highly lipophilic organochlorine compound of widespread environmental occurrence, that accumulates in the biological system. It affects the porphyrine metabolism, thyroid hormones, and the liver function in animals. Although HCB is one of the most common organ...