Adenoviral vector immunity: its implications and circumvention strategies

• Published in: Current gene therapy Vol. 11; no. 4; p. 307
• Main Authors: Ahi, Yadvinder S, Bangari, Dinesh S, Mittal, Suresh K
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.08.2011
• Subjects: Adenoviridae - genetics; Adenoviridae - immunology; Animals; Capsid - metabolism; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors - immunology; Genetic Vectors - toxicity; Helper Viruses - metabolism; Humans; Immunity, Innate; Immunosuppression; Transduction, Genetic; Transgenes; Vaccines - genetics; Vaccines - immunology

Adenoviral (Ad) vectors have emerged as a promising gene delivery platform for a variety of therapeutic and vaccine purposes during last two decades. However, the presence of preexisting Ad immunity and the rapid development of Ad vector immunity still pose significant challenges to the clinical use...