Rare familial 16q21 microdeletions under a linkage peak implicate cadherin 8 (CDH8) in susceptibility to autism and learning disability - Pagnamenta, Alistair T; Khan, Hameed; Walker, Susan; Gerrelli, Dianne; Wing, Kirsty; Bonaglia, Maria Clara; Giorda, Roberto; Berney, Tom; Mani, Elisa; Molteni, Massimo; Pinto, Dalila; Le Couteur, Ann; et al. (Journal of medical genetics, 2011)
Keywords: Adolescent; Autism; autistic; Autistic Disorder - genetics; Base Sequence; Behavior; Biological and medical sciences; Cadherins - genetics; Cadherins - metabolism; CDH8; Child; Child clinical studies; Chromosome Deletion; Chromosomes, Human, Pair 16 - genetics; Classical genetics, quantitative genetics, hybrids; CNV; Communication; Developmental disorders; Disability; DNA Copy Number Variations - genetics; DNA Mutational Analysis; Epilepsy; Family; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Gene loci; General aspects. Genetic counseling; Genetic Linkage; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genome, Human - genetics; Genomes; Human; Humans; in situ; Infantile autism; Intelligence Tests; Internet; Learning disabilities; Learning Disabilities - genetics; Male; Medical genetics; Medical sciences; Mental disorders; Molecular and cellular biology; molecular genetics; Molecular Sequence Data; neurology; Original; Pedigree; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; synapse; Young Adult; United States--US; California; Genetic mapping; Human; Microdeletion; Nervous system diseases; Family study; Pathogenesis; Cell adhesion molecule; Developmental disorder; Cadherin; Genetic determinism; Autism; Learning disability; Genetic linkage; Predisposition; Genetics; Peak; Neurological disorder; Molecular genetics; Neurology