On type 1 diabetes mellitus pathogenesis

• Published in: Endocrine Connections Vol. 7; no. 1; pp. R38 - R46
• Main Authors: Paschou, Stavroula A, Papadopoulou-Marketou, Nektaria, Chrousos, George P, Kanaka-Gantenbein, Christina
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.01.2018; Bioscientifica
• Subjects: autoimmunity; genetics; microbiota; pathogenesis; Review; type 1 diabetes; microbiota; pathogenesis; type 1 diabetes; genetics; autoimmunity

Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of β cells of the endocrine pancreas. Pathogenesis of T1DM is different from that of type 2 diabetes mellitus, where both insulin resistance and reduced secretion of insulin by the β cells play a synergistic role. We will presen...